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2 0 % - A c c e n t 5 ef %
20% - Accent6M 2
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40% - Accent2M #
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4 0 % - A c c e n t 3 L %
40% - Accent4M +
4 0 % - A c c e n t 4 L %
40% - Accent5M /
4 0 % - A c c e n t 5 L %
40% - Accent6M 3
4 0 % - A c c e n t 6 L %
60% - Accent1M
6 0 % - A c c e n t 1 23 %
60% - Accent2M $
6 0 % - A c c e n t 2 23 %
60% - Accent3M (
6 0 % - A c c e n t 3 23 %
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6 0 % - A c c e n t 6 23Ў % " Accent1A A c c e n t 1 Dr % # Accent2A ! A c c e n t 2 }1 % $ Accent3A % A c c e n t 3 % % Accent4A ) A c c e n t 4 % & Accent5A - A c c e n t 5 [ % ' Accent6A 1 A c c e n t 6 pG % ( Bad9 B a d % ) Calculation C a l c u l a t i o n } % *
Check Cell
C h e c k C e l l % ??? ??? ??? ??? + C o m m a ,( C o m m a [ 0 ] -& C u r r e n c y .. C u r r e n c y [ 0 ] / Explanatory TextG 5 E x p l a n a t o r y T e x t % 0 Good; G o o d a % 1 Heading 1G H e a d i n g 1 DTj% Dr 2 Heading 2G H e a d i n g 2 DTj% ? 3 Heading 3G H e a d i n g 3 DTj% 23 4 Heading 49 H e a d i n g 4 DTj%
5 Inputu I n p u t ̙ ??v% 6 Linked CellK L i n k e d C e l l } % 7 NeutralA N e u t r a l W % 3 N o r m a l % 8 Noteb
N o t e 9 Outputw O u t p u t ???% ??? ??? ??? ??? :$ P e r c e n t
; Title1 T i t l e DTj%
< TotalM T o t a l % Dr Dr = Warning Text? W a r n i n g T e x t % X T a b l e S t y l e M e d i u m 2 P i v o t S t y l e L i g h t 1 6 ` | Sheet1 [ 5 U Group ID Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count KEGG hsa00590 Arachidonic acid metabolism 8/41 61/81427 CYP4F3/CYP4F2/CYP2E1/PLA2G12A/TBXAS1/PTGS1/PTGS2/ALOX12 hsa00564 Glycerophospholipid metabolism 98/81428 MBOAT2/LPCAT2/MBOAT7/PLA2G12A/GPCPD1/AGPAT5/LCLAT1/CEPT1 hsa00561 Glycerolipid metabolism 5/41 MBOAT2/DGAT2/AGPAT5/GK/LCLAT1 hsa04975 Fat digestion and absorption 4/41 43/8142 CD36/ABCA1/DGAT2/PLA2G12A hsa00565 Ether lipid metabolism 49/8142 LPCAT2/PLA2G12A/GDPD3/CEPT1 hsa05204% Chemical carcinogenesis - DNA adducts 69/8142 HSD11B1/CYP1B1/CYP2E1/PTGS2 hsa03320 PPAR signaling pathway 75/8142 ACSL1/CD36/CYP27A1/GK hsa04979 Cholesterol metabolism 3/41 50/8142 CD36/ABCA1/CYP27A1 hsa04923% Regulation of lipolysis in adipocytes 56/8142 ABHD5/PTGS1/PTGS2 hsa00120 Primary bile acid biosynthesis 2/41 17/8142
CH25H/CYP27A1 hsa00140 Steroid hormone biosynthesis HSD11B1/CYP1B1/CYP2E1 hsa00980, Metabolism of xenobiotics by cytochrome P450 78/8142 hsa04146
Peroxisome 82/8142 ACSL1/CROT/PHYH hsa00062 Fatty acid elongation 27/8142 ELOVL4/THEM4 hsa00591 Linoleic acid metabolism 29/8142 CYP2E1/PLA2G12A BP
GO:0006631 fatty acid metabolic process 20/49 390/18723} ACSL1/ABHD5/CD36/CYP1B1/CYP4F3/ELOVL4/DGAT2/CYP4F2/CYP2E1/CROT/THEM4/TBXAS1/ASAH1/PTGS1/PTGS2/ALOX5AP/MCEE/PHYH/ALOX12/INSIG2
GO:0046486 glycerolipid metabolic process 18/49 392/18723s ACSL1/ABHD5/MBOAT2/LPCAT2/DGAT2/BMX/MBOAT7/CYP2E1/GPCPD1/AGPAT5/GK/PIK3C2B/GDPD3/LCLAT1/CEPT1/SLC44A3/PNPLA4/INSIG2
GO:0006644 phospholipid metabolic process 16/49 383/18723j ABHD5/PLBD1/MBOAT2/LPCAT2/BMX/MBOAT7/PLA2G12A/GPCPD1/GGPS1/AGPAT5/PIK3C2B/GDPD3/SGMS2/LCLAT1/CEPT1/SLC44A3
GO:0016042 lipid catabolic process 15/49 320/18723b ABHD5/PLBD1/HSD11B1/CYP1B1/CYP4F3/CYP27A1/CYP4F2/PLA2G12A/GPCPD1/CROT/ASAH1/GDPD3/MCEE/PHYH/PNPLA4
GO:0045017! glycerolipid biosynthetic process 12/49 252/18723J ACSL1/ABHD5/LPCAT2/DGAT2/BMX/MBOAT7/AGPAT5/GK/PIK3C2B/LCLAT1/CEPT1/SLC44A3
GO:0008654! phospholipid biosynthetic process 253/18723N ABHD5/MBOAT2/LPCAT2/BMX/MBOAT7/GGPS1/AGPAT5/PIK3C2B/SGMS2/LCLAT1/CEPT1/SLC44A3
GO:0019369" arachidonic acid metabolic process 8/49 59/187235 CYP1B1/CYP4F3/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX12
GO:0120254# olefinic compound metabolic process 10/49 153/18723B CYP1B1/CYP4F3/DGAT2/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/PNPLA4/ALOX12
GO:0001676' long-chain fatty acid metabolic process 9/49 112/18723; ACSL1/CYP1B1/CYP4F3/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX12
GO:0006650% glycerophospholipid metabolic process 306/18723O ABHD5/MBOAT2/LPCAT2/BMX/MBOAT7/GPCPD1/AGPAT5/PIK3C2B/GDPD3/LCLAT1/CEPT1/SLC44A3
GO:0033559( unsaturated fatty acid metabolic process 116/18723< CYP1B1/CYP4F3/ELOVL4/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX12
GO:0006690 icosanoid metabolic process 123/18723= CYP1B1/CYP4F3/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX5AP/ALOX12
GO:0006639 acylglycerol metabolic process 128/187237 ACSL1/ABHD5/DGAT2/MBOAT7/CYP2E1/AGPAT5/GK/PNPLA4/INSIG2
GO:0006638 neutral lipid metabolic process 129/18723
GO:0044242 cellular lipid catabolic process 214/18723; ABHD5/PLBD1/CYP1B1/GPCPD1/CROT/ASAH1/GDPD3/MCEE/PHYH/PNPLA4
GO:0006641 triglyceride metabolic process 100/187230 ACSL1/ABHD5/DGAT2/MBOAT7/CYP2E1/GK/PNPLA4/INSIG2
GO:0008202 steroid metabolic process 11/49 319/18723H CH25H/ABCA1/HSD11B1/CYP1B1/DGAT2/CYP27A1/CYP2E1/ARV1/ASAH1/STARD4/INSIG2
GO:0006066 alcohol metabolic process 353/18723B CH25H/ABCA1/CYP1B1/DGAT2/CYP27A1/ARV1/ASAH1/GK/GDPD3/PNPLA4/INSIG2
GO:0046474( glycerophospholipid biosynthetic process 211/18723; ABHD5/LPCAT2/BMX/MBOAT7/AGPAT5/PIK3C2B/LCLAT1/CEPT1/SLC44A3
GO:0072330( monocarboxylic acid biosynthetic process= ELOVL4/CYP27A1/CYP2E1/TBXAS1/PTGS1/PTGS2/STARD4/ALOX12/INSIG2
GO:0046394$ carboxylic acid biosynthetic process 314/18723E ELOVL4/CYP27A1/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX5AP/STARD4/ALOX12/INSIG2
GO:0016053! organic acid biosynthetic process 316/18723
GO:0070542 response to fatty acid 6/49 64/18723$ ACSL1/CD36/DGAT2/TBXAS1/PTGS2/INSIG2
GO:0046470% phosphatidylcholine metabolic process 74/18723( MBOAT2/LPCAT2/MBOAT7/GDPD3/CEPT1/SLC44A3
GO:1901568' fatty acid derivative metabolic process' ACSL1/CYP4F3/ELOVL4/DGAT2/CYP4F2/ALOX12
GO:0030258 lipid modification 212/187232 MBOAT2/DGAT2/MBOAT7/CYP2E1/CROT/PHYH/STARD4/ALOX12
GO:0016125 sterol metabolic process 7/49 152/18723, CH25H/ABCA1/CYP1B1/DGAT2/CYP27A1/ARV1/INSIG2
GO:0019216% regulation of lipid metabolic process 331/187238 ABHD5/DGAT2/MBOAT7/ARV1/ASAH1/PTGS2/ORMDL2/STARD4/INSIG2
GO:0010876 lipid localization 448/18723= ACSL1/ABHD5/CD36/ABCA1/DGAT2/CYP4F2/PLA2G12A/CROT/ARV1/STARD4
GO:0006633 fatty acid biosynthetic process 163/18723. ELOVL4/CYP2E1/TBXAS1/PTGS1/PTGS2/ALOX12/INSIG2
GO:0006636+ unsaturated fatty acid biosynthetic process 5/49 51/18723 ELOVL4/TBXAS1/PTGS1/PTGS2/ALOX12
GO:0006720 isoprenoid metabolic process% CYP1B1/DGAT2/CYP2E1/GGPS1/PHYH/PNPLA4
GO:0008203 cholesterol metabolic process 137/18723% CH25H/ABCA1/DGAT2/CYP27A1/ARV1/INSIG2
GO:0006691 leukotriene metabolic process 4/49 35/18723 CYP4F3/CYP4F2/ALOX5AP/ALOX12
GO:1902652# secondary alcohol metabolic process 147/18723
GO:1901617- organic hydroxy compound biosynthetic process 237/18723- CH25H/CYP27A1/ARV1/ASAH1/STARD4/ALOX12/INSIG2
GO:0015908 fatty acid transport 86/18723 ACSL1/CD36/CYP4F2/PLA2G12A/CROT
GO:0019915
lipid storage 87/18723 ABHD5/CD36/ABCA1/DGAT2/STARD4
GO:0006721 terpenoid metabolic process 97/18723 CYP1B1/DGAT2/CYP2E1/GGPS1/PNPLA4
GO:0046890( regulation of lipid biosynthetic process 171/18723& DGAT2/ASAH1/PTGS2/ORMDL2/STARD4/INSIG2
GO:0006694 steroid biosynthetic process 173/18723& CH25H/CYP27A1/ARV1/ASAH1/STARD4/INSIG2
GO:0036151) phosphatidylcholine acyl-chain remodeling 3/49 14/18723 MBOAT2/LPCAT2/MBOAT7
GO:0019218' regulation of steroid metabolic process DGAT2/ARV1/ASAH1/STARD4/INSIG2
GO:1905952 regulation of lipid localization 181/18723" ACSL1/ABHD5/CD36/ABCA1/CYP4F2/ARV1
GO:0006869 lipid transport 398/187231 ACSL1/CD36/ABCA1/CYP4F2/PLA2G12A/CROT/ARV1/STARD4
GO:0046456 icosanoid biosynthetic process 56/18723 TBXAS1/PTGS1/PTGS2/ALOX5AP
GO:0006643 membrane lipid metabolic process 203/18723% CYP1B1/ELOVL4/ARV1/ASAH1/SGMS2/ORMDL2
GO:0019373 epoxygenase P450 pathway 19/18723 CYP1B1/CYP4F2/CYP2E1
GO:0072329% monocarboxylic acid catabolic process 122/18723 CYP4F3/CYP4F2/CROT/MCEE/PHYH
GO:0042180! cellular ketone metabolic process' CYP4F3/DGAT2/CYP4F2/PTGS2/STARD4/INSIG2
GO:0033865) nucleoside bisphosphate metabolic process ACSL1/ELOVL4/DGAT2/CROT/MCEE
GO:0033875- ribonucleoside bisphosphate metabolic process
GO:00340320 purine nucleoside bisphosphate metabolic process
GO:0010878 cholesterol storage 21/18723 CD36/ABCA1/STARD4
GO:0046503 glycerolipid catabolic process 65/18723 ABHD5/GPCPD1/GDPD3/PNPLA4
GO:0035336+ long-chain fatty-acyl-CoA metabolic process 25/18723 ACSL1/ELOVL4/DGAT2
GO:1901616* organic hydroxy compound catabolic process 78/18723 CYP4F3/CYP27A1/CYP4F2/GK
GO:0044282 small molecule catabolic process 376/18723' CYP4F3/CYP27A1/CYP4F2/CROT/GK/MCEE/PHYH
GO:0006665 sphingolipid metabolic process 155/18723 ELOVL4/ARV1/ASAH1/SGMS2/ORMDL2
GO:0032366 intracellular sterol transport 29/18723 ABCA1/ARV1/STARD4
GO:0032367# intracellular cholesterol transport
GO:0001516" prostaglandin biosynthetic process 31/18723 TBXAS1/PTGS1/PTGS2
GO:0046457 prostanoid biosynthetic process
GO:0055088 lipid homeostasis 167/18723 ABHD5/ABCA1/DGAT2/ORMDL2/PNPLA4
GO:0006654& phosphatidic acid biosynthetic process 33/18723 ABHD5/AGPAT5/LCLAT1
GO:0000038, very long-chain fatty acid metabolic process 34/18723 ACSL1/ELOVL4/CYP4F2
GO:0071466( cellular response to xenobiotic stimulus 177/18723< ACSL1/ABCA1/CYP1B1/CYP4F2/CYP2E1
GO:0006637 acyl-CoA metabolic process 96/18723 ACSL1/ELOVL4/DGAT2/MCEE
GO:0035383 thioester metabolic process
GO:0046473# phosphatidic acid metabolic process 37/18723
GO:0035337 fatty-acyl-CoA metabolic process 38/18723
GO:0098869 cellular oxidant detoxification 101/18723 CD36/PTGS1/PTGS2/ALOX5AP
GO:0090207, regulation of triglyceride metabolic process 39/18723 ABHD5/DGAT2/MBOAT7
GO:0034308! primary alcohol metabolic process 102/18723 CYP1B1/DGAT2/GDPD3/PNPLA4
GO:0019395 fatty acid oxidation 103/18723 DGAT2/CROT/PHYH/ALOX12
GO:0030148! sphingolipid biosynthetic process ELOVL4/ASAH1/SGMS2/ORMDL2
GO:0019432! triglyceride biosynthetic process 42/18723 ACSL1/DGAT2/GK
GO:0034440 lipid oxidation 108/18723
GO:0032365 intracellular lipid transport 43/18723
GO:1905954) positive regulation of lipid localization 110/18723 ACSL1/CD36/ABCA1/CYP4F2
GO:0051235 maintenance of location 327/18723$ ABHD5/CD36/ABCA1/DGAT2/STARD4/INSIG2
GO:0006805 xenobiotic metabolic process 111/18723 ACSL1/CYP1B1/CYP4F2/CYP2E1
GO:0006775% fat-soluble vitamin metabolic process 44/18723 CYP4F3/CYP27A1/CYP4F2
GO:0019751 polyol metabolic process 114/18723 DGAT2/CYP27A1/ASAH1/GK
GO:1990748 cellular detoxification
GO:0030301 cholesterol transport 117/18723 CD36/ABCA1/ARV1/STARD4
GO:0006692 prostanoid metabolic process 49/18723
GO:0006693 prostaglandin metabolic process
GO:0008206 bile acid metabolic process CYP27A1/ARV1/STARD4
GO:0009395 phospholipid catabolic process PLBD1/GPCPD1/GDPD3
GO:00159113 long-chain fatty acid import across plasma membrane 2/49 10/18723
ACSL1/CD36
GO:0035376
sterol import CD36/STARD4
GO:0070508 cholesterol import
GO:0042572 retinol metabolic process 50/18723 CYP1B1/DGAT2/PNPLA4
GO:0046460" neutral lipid biosynthetic process
GO:0046463! acylglycerol biosynthetic process
GO:1901570* fatty acid derivative biosynthetic process ACSL1/ELOVL4/ALOX12
GO:0097237$ cellular response to toxic substance 124/18723
GO:0019372 lipoxygenase pathway 11/18723 ALOX5AP/ALOX12
GO:0015918 sterol transport 130/18723
GO:0046395! carboxylic acid catabolic process 236/18723
GO:0016054 organic acid catabolic process 240/18723
GO:0010565/ regulation of cellular ketone metabolic process 133/18723 DGAT2/PTGS2/STARD4/INSIG2
GO:0010883 regulation of lipid storage 57/18723 ABHD5/CD36/ABCA1
GO:0046165 alcohol biosynthetic process 140/18723 CYP27A1/ARV1/ASAH1/INSIG2
GO:0016024' CDP-diacylglycerol biosynthetic process 13/18723
AGPAT5/LCLAT1
GO:0046467# membrane lipid biosynthetic process 142/18723
GO:0009636 response to toxic substance 262/18723 CD36/CYP1B1/PTGS1/PTGS2/ALOX5AP
GO:0042363% fat-soluble vitamin catabolic process
CYP4F3/CYP4F2
GO:0046341$ CDP-diacylglycerol metabolic process
GO:0032368 regulation of lipid transport 149/18723 ACSL1/ABCA1/CYP4F2/ARV1
GO:0045834. positive regulation of lipid metabolic process ABHD5/DGAT2/PTGS2/STARD4
GO:0016126 sterol biosynthetic process CH25H/ARV1/INSIG2
GO:0015909 long-chain fatty acid transport ACSL1/CD36/PLA2G12A
GO:0046513 ceramide biosynthetic process ASAH1/SGMS2/ORMDL2
GO:0098754 detoxification
GO:1905953) negative regulation of lipid localization 66/18723 ABHD5/ABCA1/CYP4F2
GO:0042182 ketone catabolic process 15/18723
GO:0046459( short-chain fatty acid metabolic process MCEE/PHYH
GO:0050810* regulation of steroid biosynthetic process 69/18723 ASAH1/STARD4/INSIG2
GO:0009111 vitamin catabolic process 16/18723
GO:0046488& phosphatidylinositol metabolic process 159/18723 BMX/MBOAT7/PIK3C2B/LCLAT1
GO:0044539& long-chain fatty acid import into cell 17/18723
GO:0140354 lipid import into cell
GO:1901569' fatty acid derivative catabolic process
GO:1902001" fatty acid transmembrane transport 18/18723
GO:0006809! nitric oxide biosynthetic process 76/18723 CD36/CYP1B1/PTGS2
GO:0001659 temperature homeostasis 174/18723 ACSL1/CD36/G0S2/PTGS2
GO:0006071 glycerol metabolic process DGAT2/GK
GO:0010885! regulation of cholesterol storage
CD36/ABCA1
GO:0035338. long-chain fatty-acyl-CoA biosynthetic process ACSL1/ELOVL4
GO:0015849 organic acid transport 303/18723
GO:0009410 response to xenobiotic stimulus 462/18723& ACSL1/ABCA1/CYP1B1/CYP4F2/CYP2E1/PTGS2
GO:0001523 retinoid metabolic process 81/18723
GO:0046209 nitric oxide metabolic process
GO:00468891 positive regulation of lipid biosynthetic process 82/18723 DGAT2/PTGS2/STARD4
GO:2001057+ reactive nitrogen species metabolic process
GO:0032370& positive regulation of lipid transport 84/18723 ACSL1/ABCA1/CYP4F2
GO:00970060 regulation of plasma lipoprotein particle levels 85/18723 CD36/ABCA1/DGAT2
GO:0019400 alditol metabolic process 22/18723
GO:0071404> cellular response to low-density lipoprotein particle stimulus
GO:2000193+ positive regulation of fatty acid transport ACSL1/CYP4F2
GO:0016101 diterpenoid metabolic process
GO:0010888$ negative regulation of lipid storage 23/18723 ABHD5/ABCA1
GO:00902085 positive regulation of triglyceride metabolic process ABHD5/DGAT2
GO:0062012. regulation of small molecule metabolic process 334/18723 DGAT2/ARV1/PTGS2/STARD4/INSIG2
GO:0019217* regulation of fatty acid metabolic process 93/18723 DGAT2/PTGS2/INSIG2
GO:0036315 cellular response to sterol ABCA1/INSIG2
GO:0046949# fatty-acyl-CoA biosynthetic process
GO:01201621 positive regulation of cold-induced thermogenesis ACSL1/CD36/G0S2
GO:0006706 steroid catabolic process 26/18723 HSD11B1/CYP27A1
GO:0018904 ether metabolic process 27/18723
LPCAT2/ALOX12
GO:0009062 fatty acid catabolic process CROT/MCEE/PHYH
GO:0006672 ceramide metabolic process
GO:0045833. negative regulation of lipid metabolic process DGAT2/ORMDL2/INSIG2
GO:00026752 positive regulation of acute inflammatory response 28/18723
PTGS2/ALOX5AP
GO:0010575D positive regulation of vascular endothelial growth factor production CYP1B1/PTGS2
GO:0006656( phosphatidylcholine biosynthetic process
CEPT1/SLC44A3
GO:0019433 triglyceride catabolic process ABHD5/PNPLA4
GO:0042759* long-chain fatty acid biosynthetic process
CYP2E1/ALOX12
GO:0009150' purine ribonucleotide metabolic process 368/18723
GO:0006766 vitamin metabolic process 106/18723
GO:0010743: regulation of macrophage derived foam cell differentiation 32/18723
GO:0046475% glycerophospholipid catabolic process GPCPD1/GDPD3
GO:2000191" regulation of fatty acid transport
GO:0009259 ribonucleotide metabolic process 385/18723
GO:0034383* low-density lipoprotein particle clearance
CD36/DGAT2
GO:0055094 response to lipoprotein particle
GO:0006163# purine nucleotide metabolic process 396/18723
GO:0019693" ribose phosphate metabolic process
GO:0034405 response to fluid shear stress ABCA1/PTGS2
GO:0045907' positive regulation of vasoconstriction TBXAS1/PTGS2
GO:00459223 negative regulation of fatty acid metabolic process DGAT2/INSIG2
GO:0090181+ regulation of cholesterol metabolic process
DGAT2/ARV1
GO:0006699 bile acid biosynthetic process 36/18723 CYP27A1/STARD4
GO:0036314 response to sterol
GO:0046466 membrane lipid catabolic process CYP1B1/ASAH1
GO:00714022 cellular response to lipoprotein particle stimulus
GO:0042178 xenobiotic catabolic process ACSL1/CYP2E1
GO:0010742, macrophage derived foam cell differentiation
GO:0090077 foam cell differentiation
GO:0072521, purine-containing compound metabolic process 416/18723
GO:0046461 neutral lipid catabolic process
GO:0046464 acylglycerol catabolic process
GO:0006661) phosphatidylinositol biosynthetic process 131/18723 BMX/MBOAT7/PIK3C2B
GO:0032892- positive regulation of organic acid transport 40/18723
GO:00454298 positive regulation of nitric oxide biosynthetic process
CD36/PTGS2
GO:1901661< W quinone metabolic process
GO:19044075 positive regulation of nitric oxide metabolic process 41/18723
GO:0034754" cellular hormone metabolic process
GO:0006979 response to oxidative stress 446/18723 CD36/CYP1B1/CYP2E1/PTGS1/PTGS2
GO:0032309 icosanoid secretion 45/18723 CYP4F2/PLA2G12A
GO:0035384 thioester biosynthetic process
GO:0071616 acyl-CoA biosynthetic process
GO:00620137 positive regulation of small molecule metabolic process 143/18723
GO:0106106 cold-induced thermogenesis 144/18723
GO:0120161( regulation of cold-induced thermogenesis
GO:0015850" organic hydroxy compound transport 284/18723
GO:0002673) regulation of acute inflammatory response 48/18723
GO:0120009 intermembrane lipid transfer ABCA1/STARD4
GO:0042304- regulation of fatty acid biosynthetic process PTGS2/INSIG2
GO:0046434! organophosphate catabolic process
GO:1990845 adaptive thermogenesis 157/18723
GO:0007162$ negative regulation of cell adhesion CYP1B1/TNFAIP8L2/TNFRSF21/ALOX12
GO:0034381% plasma lipoprotein particle clearance 53/18723
GO:0071715 icosanoid transport
GO:0009117 nucleotide metabolic process 489/18723
GO:0046164 alcohol catabolic process 55/18723
CYP27A1/GK
GO:0006753& nucleoside phosphate metabolic process 497/18723
GO:0006695 cholesterol biosynthetic process ARV1/INSIG2
GO:0050891* multicellular organismal water homeostasis
CYP4F2/ALOX12
GO:1902653& secondary alcohol biosynthetic process
GO:0010574; regulation of vascular endothelial growth factor production 58/18723
GO:0097035) regulation of membrane lipid distribution
ABCA1/ARV1
GO:00510551 negative regulation of lipid biosynthetic process
ORMDL2/INSIG2
GO:0007584 response to nutrient ACSL1/ABCA1/PTGS2
GO:0033866, nucleoside bisphosphate biosynthetic process 60/18723
GO:00340300 ribonucleoside bisphosphate biosynthetic process
GO:00340333 purine nucleoside bisphosphate biosynthetic process
GO:0042306) regulation of protein import into nucleus
GO:0010573- vascular endothelial growth factor production 62/18723
GO:0045428/ regulation of nitric oxide biosynthetic process
GO:0046173 polyol biosynthetic process
CYP27A1/ASAH1
GO:0006790! sulfur compound metabolic process 339/18723
GO:1904589 regulation of protein import 63/18723
GO:0030104 water homeostasis
GO:0080164, regulation of nitric oxide metabolic process
GO:0008217 regulation of blood pressure 186/18723 CYP4F2/PTGS1/PTGS2
GO:0019229 regulation of vasoconstriction
GO:0030193 regulation of blood coagulation CD36/ALOX12
GO:0032890$ regulation of organic acid transport 67/18723
GO:1900046 regulation of hemostasis 68/18723
GO:0022408) negative regulation of cell-cell adhesion 196/18723 TNFAIP8L2/TNFRSF21/ALOX12
GO:0050818 regulation of coagulation 71/18723
GO:0006801 superoxide metabolic process CC
GO:00312275 intrinsic component of endoplasmic reticulum membrane 170/19550( HSD11B1/ELOVL4/DGAT2/CYP2E1/SGMS2/INSIG2
GO:0005811
lipid droplet 96/19550 ABHD5/LPCAT2/DGAT2/G0S2/PNPLA4
GO:00301764 integral component of endoplasmic reticulum membrane 162/19550! HSD11B1/ELOVL4/DGAT2/SGMS2/INSIG2
GO:0031300) intrinsic component of organelle membrane 417/19550
GO:0031968 organelle outer membrane 230/19550 ACSL1/AGPAT5/PTGS2/GK
GO:0019867 outer membrane 232/19550
GO:0031301( integral component of organelle membrane 387/19550
GO:0005777
peroxisome 142/19550
GO:0042579 microbody
GO:0005782 peroxisomal matrix 51/19550 CROT/PHYH
GO:0031907 microbody lumen MF
GO:0008374 O-acyltransferase activity 54/183683 ABHD5/MBOAT2/LPCAT2/DGAT2/MBOAT7/CROT/AGPAT5/LCLAT1
GO:0016411' acylglycerol O-acyltransferase activity 31/18368. ABHD5/MBOAT2/LPCAT2/DGAT2/MBOAT7/AGPAT5/LCLAT1
GO:00038415 1-acylglycerol-3-phosphate O-acyltransferase activity 21/18368( ABHD5/MBOAT2/LPCAT2/MBOAT7/AGPAT5/LCLAT1
GO:0016705e oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 170/18368A CH25H/CYP1B1/CYP4F3/CYP27A1/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2/PHYH
GO:0042171. lysophosphatidic acid acyltransferase activity 23/18368
GO:0071617) lysophospholipid acyltransferase activity
GO:0005506 iron ion binding 151/18368< CH25H/CYP1B1/CYP4F3/CYP27A1/CYP4F2/CYP2E1/TBXAS1/PHYH/ALOX12
GO:0020037 heme binding 139/183686 CYP1B1/CYP4F3/CYP27A1/CYP4F2/CYP2E1/TBXAS1/PTGS1/PTGS2
GO:0046906 tetrapyrrole binding 149/18368
GO:0016747J acyltransferase activity, transferring groups other than amino-acyl groups 222/18368: ABHD5/MBOAT2/LPCAT2/ELOVL4/DGAT2/MBOAT7/CROT/AGPAT5/LCLAT1
GO:0004497 monooxygenase activity 102/183680 CH25H/CYP1B1/CYP4F3/CYP27A1/CYP4F2/CYP2E1/TBXAS1
GO:0016746 acyltransferase activity 250/18368
GO:0070330 aromatase activity 25/18368 CYP1B1/CYP4F3/CYP4F2/CYP2E1
GO:0008395 steroid hydroxylase activity 38/18368 CH25H/CYP1B1/CYP27A1/CYP2E1
GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen 40/18368
GO:0051213 dioxygenase activity 92/18368 PTGS1/PTGS2/ALOX5AP/PHYH/ALOX12
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 43/18368 CH25H/CYP27A1/CYP4F2/CYP2E1
GO:0008391' arachidonic acid monooxygenase activity CYP4F3/CYP4F2/CYP2E1
GO:0016702} oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen PTGS2/ALOX5AP/ALOX12
GO:0016701W oxidoreductase activity, acting on single donors with incorporation of molecular oxygen 24/18368
GO:0015248 sterol transporter activity 36/18368
GO:0005496 steroid binding 100/18368 ABCA1/HSD11B1/STARD4/INSIG2
GO:0004601 peroxidase activity 51/18368 PTGS1/PTGS2/ALOX5AP
GO:0016298 lipase activity 129/18368 PLBD1/PLA2G12A/GDPD3/PNPLA4
GO:00166847 oxidoreductase activity, acting on peroxide as acceptor 55/18368
GO:00166148 oxidoreductase activity, acting on CH-OH group of donors 136/18368 HSD11B1/CYP4F3/CYP27A1/CYP4F2
GO:0008035) high-density lipoprotein particle binding 13/18368
GO:0032934 sterol binding 60/18368 ABCA1/STARD4/INSIG2
GO:0052689# carboxylic ester hydrolase activity 147/18368 ABHD5/PLA2G12A/GDPD3/PNPLA4
GO:0005319 lipid transporter activity 154/18368
GO:0008392% arachidonic acid epoxygenase activity 17/18368
CYP4F2/CYP2E1
GO:0016780C phosphotransferase activity, for other substituted phosphate groups 20/18368 SGMS2/CEPT1
GO:0120020 cholesterol transfer activity 22/18368
GO:0016209 antioxidant activity 86/18368
GO:0120015 sterol transfer activity
GO:0004620 phospholipase activity 104/18368 PLBD1/PLA2G12A/GDPD3
GO:0071813 lipoprotein particle binding
GO:0071814 protein-lipid complex binding
GO:0120013 lipid transfer activity 48/18368
GO:0015485 cholesterol binding 50/18368
GO:0016765K transferase activity, transferring alkyl or aryl (other than methyl) groups 58/18368
GGPS1/ALOX5AP
GO:0016836 hydro-lyase activity 64/18368
CYP1B1/TBXAS1
GO:0016829 lyase activity 196/18368 CYP1B1/TBXAS1/ALOX5AP
GO:0038024 cargo receptor activity 77/18368
GO:0016835 carbon-oxygen lyase activity 79/18368
GO:0008081% phosphoric diester hydrolase activity 89/18368
GO:0043178 alcohol binding
GO:0016303( 1-phosphatidylinositol-3-kinase activity 1/49 10/18368 PIK3C2B
GO:0016803 ether hydrolase activity ALOX12
GO:00363128 phosphatidylinositol 3-kinase regulatory subunit binding PTPN139 Supplementary Table 1. Functional annotation of the DEGs. 1 1 c 2 a3 4 4 L5 5 m 6 7 8 @ 9 e : o ; E
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lenovo Dhanasekar Microsoft Excel @ P@ %@
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Sheet1 Worksheets
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