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> TotalM T o t a l % Dr Dr ? Warning Text? W a r n i n g T e x t % X T a b l e S t y l e M e d i u m 2 P i v o t S t y l e L i g h t 1 6 ` Additional Table S5 S \ ADAMTS9 ANKRD2 AOX1 ASPN DDX3Y DSC1 FCER1G FCN3 FRZB HBB HMGCS2 IL1RL1 LUM MGST1 MNS1 MYH6 NPPA PLA2G2A RNASE2 SERPINA3 SERPINE1 SFRP4 SLCO4A1 SMOC2 USP9Y UTY VSIG4 ID
GO:0042119 neutrophil activation
GO:00022831 neutrophil activation involved in immune response
GO:0031349' positive regulation of defense response
GO:0001819* positive regulation of cytokine production
GO:0050727# regulation of inflammatory response
GO:0042116 macrophage activation
GO:0050729, positive regulation of inflammatory response
GO:0050764 regulation of phagocytosis
GO:0030667 secretory granule membrane
GO:0101002 ficolin-1-rich granule
GO:0070820 tertiary granule
GO:0034774 secretory granule lumen
GO:0060205 cytoplasmic vesicle lumen
GO:0101003 ficolin-1-rich granule membrane Description GeneRatio BgRatio pvalue p.adjust qvalue geneID Count
GO:0060326 cell chemotaxis
GO:0002687* positive regulation of leukocyte migration
GO:0002526 acute inflammatory response
GO:0007596 blood coagulation
GO:0031983
vesicle lumen
GO:0140375 immune receptor activity
GO:0050135 NAD(P)+ nucleosidase activity LYVE1 Group 7
GO:0002460y adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains response to muscle stretch
GO:0035994 regulation of wound healing
GO:0061041 regulation of angiogenesis
GO:0045765% regulation of vasculature development- regulation of epithelial cell differentiation
GO:1901342
GO:0030856
GO:0060048. regulation of smooth muscle cell proliferation vascular wound healing
GO:0048660
GO:0061042 smooth muscle cell proliferation
GO:0048659" regulation of response to wounding
GO:1903034( positive regulation of blood coagulation! positive regulation of hemostasis
GO:0030194
GO:1900048" positive regulation of coagulation
GO:0050820 fibrinolysis
GO:0042730. negative regulation of humoral immune response$ regulation of vascular wound healing
GO:0002921
GO:0061043 acute-phase response
GO:0006953 muscle system process& angiogenesis involved in wound healing
GO:0003012
GO:0060055# positive regulation of phagocytosis
GO:0050766 liver development
GO:0001889! positive regulation of chemotaxis" hepaticobiliary system development
GO:0050921
GO:0061008 heart contraction- positive regulation of cellular extravasation
GO:0060047
GO:0002693
GO:0061809
GO:0002020 protease binding MIR208A MYH6/NPPA
FRZB/SFRP4 BP
GO:0003299( muscle hypertrophy in response to stress 3/39 31/18800 MYH6/MIR208A/NPPA
GO:0014887 cardiac muscle adaptation
GO:00148980 cardiac muscle hypertrophy in response to stress
GO:0014888 striated muscle adaptation 54/18800 2/39 14/18800 SMOC2/SERPINE1 22/18800
GO:0003300 cardiac muscle hypertrophy 96/18800
GO:0019835 cytolysis 24/18800
PLA2G2A/C6
GO:0014897 striated muscle hypertrophy 99/18800
GO:0014896 muscle hypertrophy 101/18800
GO:0002274 myeloid leukocyte activation 4/39 232/18800 VSIG4/IL1RL1/PLA2G2A/FCER1G
GO:0048738! cardiac muscle tissue development 234/18800 MYH6/ADAMTS9/MIR208A/NPPA
GO:0014706" striated muscle tissue development 248/18800
GO:00701684 negative regulation of biomineral tissue development 30/18800 ASPN/MIR208A
GO:0043500 muscle adaptation 118/18800
GO:0110150( negative regulation of biomineralization 5/39 449/18800 MYH6/MYOT/ANKRD2/MIR208A/NPPA
GO:0006956 complement activation 131/18800
FCN3/VSIG4/C6
GO:19013854 regulation of voltage-gated calcium channel activity 38/18800 MIR208A/NPPA 41/18800 PLA2G2A/FCER1G 145/18800 IL1RL1/PLA2G2A/SERPINE1
GO:0030198! extracellular matrix organization 307/18800 SMOC2/LUM/ADAMTS9/ADAMTS4
GO:0043062$ extracellular structure organization 308/18800
GO:0045229- external encapsulating structure organization 310/18800 157/18800 FRZB/SFRP4/SERPINE1
GO:0036230 granulocyte activation 47/18800 48/18800 SERPINA3/CD163
GO:00482604 positive regulation of receptor-mediated endocytosis 53/18800 SFRP4/SERPINE1
GO:0006936 muscle contraction 349/18800 MYH6/MYOT/ANKRD2/NPPA
GO:0003179 heart valve morphogenesis 55/18800 ADAMTS9/NPPA
GO:0003229- ventricular cardiac muscle tissue development 56/18800 MYH6/ADAMTS9
GO:0008217 regulation of blood pressure 183/18800
MYH6/HBB/NPPA
GO:0090303$ positive regulation of wound healing 58/18800
GO:0043030# regulation of macrophage activation 62/18800 VSIG4/IL1RL1
GO:0003170 heart valve development 65/18800
GO:00308586 positive regulation of epithelial cell differentiation
GO:0002253 activation of immune response 386/18800 FCN3/VSIG4/FCER1G/C6
GO:0008016 regulation of heart contraction 211/18800 71/18800 FCN3/FCER1G
GO:0060537 muscle tissue development 405/18800
GO:0035567# non-canonical Wnt signaling pathway 72/18800
GO:1903036+ positive regulation of response to wounding
GO:0060420 regulation of heart growth 74/18800 MYH6/MIR208A 221/18800 FCER1G/HBB/SERPINE1
GO:0050817 coagulation 226/18800
GO:0007599
hemostasis 227/18800
GO:0042060
wound healing 429/18800 SMOC2/FCER1G/HBB/SERPINE1
GO:0055013 cardiac muscle cell development 81/18800
GO:0007160 cell-matrix adhesion 235/18800 LYVE1/ADAMTS9/SERPINE1
GO:00321034 positive regulation of response to external stimulus 442/18800 SMOC2/IL1RL1/PLA2G2A/SERPINE1
GO:0055006 cardiac cell development 87/18800
GO:0006898 receptor-mediated endocytosis 246/18800 SFRP4/FCER1G/SERPINE1 247/18800
GO:1901019< regulation of calcium ion transmembrane transporter activity 91/18800
GO:0003015
heart process 257/18800
GO:0071559+ response to transforming growth factor beta 258/18800 ASPN/MXRA5/USP9Y
GO:1904035/ regulation of epithelial cell apoptotic process 94/18800 475/18800 LUM/IL1RL1/FCER1G/SERPINE1
GO:1903522 regulation of blood circulation 260/18800
GO:0060419 heart growth
GO:0045807" positive regulation of endocytosis 97/18800
GO:0098869 cellular oxidant detoxification 100/18800 MGST1/HBB
GO:0046620 regulation of organ growth
GO:0070167+ regulation of biomineral tissue development
GO:0110149 regulation of biomineralization 103/18800
GO:0002027 regulation of heart rate 105/18800 106/18800
GO:0007168+ receptor guanylyl cyclase signaling pathway 1/39 10/18800
GO:0032754/ positive regulation of interleukin-5 production
GO:0051918# negative regulation of fibrinolysis
GO:0070327 thyroid hormone transport
GO:1902224 ketone body metabolic process
GO:1903027 regulation of opsonization
GO:0048259+ regulation of receptor-mediated endocytosis 110/18800 289/18800
GO:0051607 defense response to virus 290/18800 FCN3/RNASE2/IFI44L
GO:0140546 defense response to symbiont 291/18800
GO:0006182 cGMP biosynthetic process 11/18800
GO:0007494 midgut development
GO:0043619[ regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0086016 AV node cell action potential
GO:0086027, AV node cell to bundle of His cell signaling
GO:00996242 atrial cardiac muscle cell membrane repolarization 113/18800
GO:0031623 receptor internalization SFRP4/FCER1G
GO:1990748 cellular detoxification 115/18800
GO:0001867% complement activation, lectin pathway 12/18800
GO:0010455+ positive regulation of cell fate commitment
GO:00329089 regulation of transforming growth factor beta1 production
GO:00336299 negative regulation of cell adhesion mediated by integrin
GO:0045916, negative regulation of complement activation
GO:0070170" regulation of tooth mineralization
GO:00860670 AV node cell to bundle of His cell communication
GO:1904019! epithelial cell apoptotic process
GO:0030282 bone mineralization 121/18800
GO:0055007# cardiac muscle cell differentiation
GO:0055062< phosphate ion homeostasis 13/18800
GO:0072506% trivalent inorganic anion homeostasis
GO:0097237$ cellular response to toxic substance 123/18800
GO:00902879 regulation of cellular response to growth factor stimulus 314/18800 SMOC2/SFRP4/ASPN 315/18800 SMOC2/FCER1G/SERPINE1
GO:0006959 humoral immune response 317/18800
GO:0007512 adult heart development
GO:0014744( positive regulation of muscle adaptation
GO:0030049 muscle filament sliding
GO:00459892 positive regulation of striated muscle contraction
GO:0048070( regulation of developmental pigmentation
GO:0051917 regulation of fibrinolysis
GO:0070986 left/right axis specification
GO:0120305 regulation of pigmentation
GO:19018419 regulation of high voltage-gated calcium channel activity
GO:0045931) positive regulation of mitotic cell cycle 128/18800
SMOC2/MIR208A
GO:0030168 platelet activation 130/18800
FCER1G/HBB
GO:0042476
odontogenesis
ASPN/SERPINE1
GO:0010755$ regulation of plasminogen activation 15/18800
GO:0015671 oxygen transport
GO:0032905+ transforming growth factor beta1 production
GO:0043252* sodium-independent organic anion transport
GO:0060026 convergent extension
GO:0070365 hepatocyte differentiation
GO:0090281) negative regulation of calcium ion import
GO:1902514X regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
GO:1902563# regulation of neutrophil activation
GO:20010282 positive regulation of endothelial cell chemotaxis 133/18800 134/18800 FRZB/HMGCS2 16/18800
GO:0006857 oligopeptide transport
GO:0008228 opsonization
GO:0033275 actin-myosin filament sliding
GO:0034374+ low-density lipoprotein particle remodeling
GO:0043508* negative regulation of JUN kinase activity
GO:0046068 cGMP metabolic process 137/18800 cardiac muscle contraction 138/18800 140/18800 345/18800 SMOC2/ADAMTS9/SERPINE1 141/18800 LYVE1/SERPINE1
GO:0016114 terpenoid biosynthetic process 17/18800
GO:0033194 response to hydroperoxide
GO:0061577J calcium ion transmembrane transport via high voltage-gated calcium channel
GO:0090399 replicative senescence
GO:1903818? positive regulation of voltage-gated potassium channel activity
GO:00900906 negative regulation of canonical Wnt signaling pathway 142/18800 351/18800 18/18800
GO:0006957* complement activation, alternative pathway
GO:0010612' regulation of cardiac muscle adaptation
GO:1903242> regulation of cardiac muscle hypertrophy in response to stress
GO:0016525# negative regulation of angiogenesis 149/18800 ADAMTS9/SERPINE1
GO:0015711 organic anion transport 361/18800 SLCO4A1/PLA2G2A/MGST1
GO:0098754 detoxification 150/18800 19/18800
GO:0010744C positive regulation of macrophage derived foam cell differentiation
GO:0032634 interleukin-5 production
GO:0032674& regulation of interleukin-5 production
GO:0043031, negative regulation of macrophage activation
GO:1901386= negative regulation of voltage-gated calcium channel activity
GO:20001811 negative regulation of blood vessel morphogenesis 151/18800
GO:0031589 cell-substrate adhesion 364/18800
GO:0042742 defense response to bacterium PLA2G2A/FCER1G/SERPINE1
GO:1901343. negative regulation of vasculature development 152/18800
GO:0035051 cardiocyte differentiation 153/18800
GO:0007178H transmembrane receptor protein serine/threonine kinase signaling pathway 368/18800 SFRP4/ASPN/USP9Y
GO:0003228( atrial cardiac muscle tissue development 20/18800
GO:00105239 negative regulation of calcium ion transport into cytosol
GO:0061050E regulation of cell growth involved in cardiac muscle cell development
GO:0070293 renal absorption
GO:0090026* positive regulation of monocyte chemotaxis
GO:0097623+ potassium ion export across plasma membrane 370/18800 IL1RL1/FCER1G/C6
GO:0043271$ negative regulation of ion transport 155/18800
SFRP4/MIR208A
GO:19031691 regulation of calcium ion transmembrane transport 156/18800
GO:00030857 negative regulation of systemic arterial blood pressure 21/18800
GO:0015669
gas transport
GO:0030449# regulation of complement activation
GO:0030502* negative regulation of bone mineralization
GO:0033762 response to glucagon
GO:0071404> cellular response to low-density lipoprotein particle stimulus
GO:0071636A positive regulation of transforming growth factor beta production
GO:1902259: regulation of delayed rectifier potassium channel activity
GO:0050878 regulation of body fluid levels 382/18800
GO:0030509 BMP signaling pathway 162/18800 SFRP4/USP9Y
GO:0009190& cyclic nucleotide biosynthetic process
GO:0030277* maintenance of gastrointestinal epithelium
GO:00465971 negative regulation of viral entry into host cell
GO:0052652* cyclic purine nucleotide metabolic process
GO:0060972 left/right pattern formation
GO:0086012C membrane depolarization during cardiac muscle cell action potential
GO:0050900 leukocyte migration 384/18800 LYVE1/FCER1G/SERPINE1 166/18800 23/18800
GO:0009615 response to virus 392/18800
GO:0007156? homophilic cell adhesion via plasma membrane adhesion molecules 168/18800 MYOT/DSC1 394/18800
GO:1901136) carbohydrate derivative catabolic process 169/18800
LYVE1/ADAMTS9
GO:0031214 biomineral tissue development 170/18800 OGN/MIR208A
GO:0038095% Fc-epsilon receptor signaling pathway
GO:0060563$ neuroepithelial cell differentiation
GO:0090103 cochlea morphogenesis
GO:1903792& negative regulation of anion transport
GO:2001026) regulation of endothelial cell chemotaxis
GO:0110148 biomineralization 172/18800 173/18800
GO:0071772 response to BMP
GO:0071773! cellular response to BMP stimulus CC
GO:0062023( collagen-containing extracellular matrix 11/39 429/19594D SERPINA3/FCN3/SMOC2/LUM/OGN/ASPN/ADAMTS9/MXRA5/ADAMTS4/SERPINE1/NPPA
GO:0005775 vacuolar lumen 174/19594 SERPINA3/LUM/OGN/RNASE2
GO:0031674 I band 139/19594 MYH6/MYOT/ANKRD2
GO:0072562 blood microparticle 147/19594 SERPINA3/FCN3/HBB
GO:0005766 primary lysosome 155/19594 SERPINA3/RNASE2/MGST1
GO:0042582 azurophil granule 164/19594 FCER1G/DSC1/HBB 185/19594 61/19594 FCER1G/DSC1
GO:0031093 platelet alpha granule lumen 67/19594 SERPINA3/SERPINE1
GO:0030017 sarcomere 209/19594
GO:0030016 myofibril 228/19594
GO:0043292 contractile fiber 238/19594
GO:0005581 collagen trimer 86/19594 FCN3/LUM
GO:0031091 platelet alpha granule 91/19594
GO:0035578 azurophil granule lumen SERPINA3/RNASE2
GO:0043202 lysosomal lumen 97/19594 LUM/OGN
GO:0005796 Golgi lumen 104/19594
GO:0031838 haptoglobin-hemoglobin complex 11/19594
GO:1904090 peptidase inhibitor complex
GO:1905286 serine-type peptidase complex
GO:0005583 fibrillar collagen trimer 12/19594
GO:0005833 hemoglobin complex
GO:0098643 banded collagen fibril 312/19594 FCER1G/MGST1/DSC1 322/19594 SERPINA3/RNASE2/SERPINE1
GO:0030018 Z disc 127/19594 MYH6/MYOT 325/19594 327/19594
GO:0044666 MLL3/4 complex 14/19594
GO:0005859 muscle myosin complex 15/19594
GO:0016460 myosin II complex 22/19594
GO:0032982 myosin filament
GO:0098644 complex of collagen trimers
GO:0071682 endocytic vesicle lumen 23/19594
GO:0030057 desmosome 25/19594
GO:0043186 P granule
GO:0045495
pole plasm
GO:0060293
germ plasm MF
GO:0030021M extracellular matrix structural constituent conferring compression resistance 22/18410 LUM/OGN/ASPN
GO:0005201+ extracellular matrix structural constituent 172/18410 LUM/OGN/ASPN/MXRA5
GO:0017147 Wnt-protein binding 30/18410
GO:0019825 oxygen binding 39/18410
CYP4B1/HBB
GO:0008307 structural constituent of muscle 42/18410 MYOT/ANKRD2
GO:0004601 peroxidase activity 52/18410
GO:00166847 oxidoreductase activity, acting on peroxide as acceptor 56/18410
GO:0005518 collagen binding 68/18410 LUM/ASPN<
GO:0016209 antioxidant activity 85/18410
GO:0004867, serine-type endopeptidase inhibitor activity 98/18410
GO:0031720 haptoglobin binding 10/18410
GO:0019864 IgG binding 11/18410
GO:0043422 protein kinase B binding
GO:0070410 co-SMAD binding
GO:0004222 metalloendopeptidase activity 111/18410 ADAMTS9/ADAMTS4
GO:0005344 oxygen carrier activity 14/18410
GO:0016894l endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters 15/18410
GO:0001846 opsonin binding 16/18410
GO:0015347C sodium-independent organic anion transmembrane transporter activity
GO:0047498+ calcium-dependent phospholipase A2 activity/ NAD+ nucleotidase, cyclic ADP-ribose generating 136/18410 ADAMTS4/SERPINE1
GO:0020037 heme binding 139/18410 148/18410
IL1RL1/FCER1G
GO:0046906 tetrapyrrole binding 149/18410
GO:0005506 iron ion binding 151/18410 AOX1/CYP4B1
GO:0001848 complement binding 20/18410
GO:0004602 glutathione peroxidase activity
GO:0005540 hyaluronic acid binding 24/18410
GO:0019865 immunoglobulin binding
GO:0051537 2 iron, 2 sulfur cluster binding2 Supplementary Table 5. GO analysis of the 39 DEGs. b 2 3 L N3 3 4 R 4 5 76 p 6 .7 g 7 8 9 m: -; f ; < = J
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x Additional Table S5 Worksheets
! " # $ % & ' ( ) * + , - . / 0 1 2 3 4 5 6 7 8 9 : ; < = > ? @ A B C D E F G H I J K L M N O P Q R S T U V W X Y Z [ \ ] ^ _ ` a b c d e f g h i j k l m n o p q r s t u v w x y z { | } ~ R o o t E n t r y F `P!E W o r k b o o k K S u m m a r y I n f o r m a t i o n ( D o c u m e n t S u m m a r y I n f o r m a t i o n 8