Research Paper Volume 5, Issue 2 pp 111—119

Figure 2. Effect of rapamycin on mTOR signaling and radiation-induced tumor development. (A) Western blotting and quantitative analysis of the blots shows decreased p-s6rp (Ser240 and Ser244) level in spleen when mice treated with rapamycin. No change was found in total s6rp. Mean values (± standard deviation) were presented. The p-values were obtained by t-test. (B) Radiation-induced tumorigenesis in Fbxw7+/−p53+/− or p53+/− mice with 10-week treatment of rapamycin or placebo that was given at 1 week post a single dose of 4Gy X-ray radiation. Top panel: Kaplan-Meier curves of tumor latency. Bottom panel: The p-values were obtained from long rank test by Kaplan-Meier analysis.