Research Paper Volume 8, Issue 7 pp 1330—1349

Figure 4. Mitophagy deficiency impairs the metabolome remodeling associated with nuclear reprogramming. Left. Heatmap to view the agglomerative hierarchical clustering of the PINK1^+/+- and PINK1^−/−-iPSCs groups analyzed with MetaboAnalyst's data annotation tool [103]. Rows: metabolites; columns: samples; color key indicates metabolite expression value (blue: lowest; red: highest). Right. Heatmap of correlations between iPSCs metabolites. Each square represents the Spearman's correlation coefficient between the metabolite of the column with that of the row. Metabolite order is determined as in hierarchical clustering using the distance function 1-correlation. Self-self correlations are identified in dark brown.