Research Paper Volume 8, Issue 7 pp 1330—1349

Figure 6. Mitophagy deficiency reduces tumorigenicity of iPSC colonies. Athymic mice were injected with 5 × 10⁵ or 2 × 10⁶ cells obtained from PINK1^+/+-iPSC or PINK1^−/−-iPSC colonies. Teratoma growth rate was calculated by measuring teratoma volume. (A) Kaplan-Meier plots show the percentage of mice that remained teratoma-free after subcutaneous injection of iPSCs obtained as described in Fig. 2. (B) Mean teratoma volumes obtained at the end of the experiment (left) as well as representative images of animals bearing PINK1^+/+-iPSC- and PINK1^−/−-iPSC-derived teratomas after injection with 2 × 10⁶ cells (right). Note that teratomas formed from PINK1^+/+-iPSCs present a dramatically higher growth rate that those derived from PINK1^−/−-iPSCs.