Research Paper Volume 11, Issue 16 pp 6371—6384

MiR-27a promotes the autophagy and apoptosis of IL-1β treated-articular chondrocytes in osteoarthritis through PI3K/AKT/mTOR signaling


Figure 2. The miR-27a expression in OA cartilage and IL-1β-triggered chondrocytes. (A) miR-27a expression in normal (n=10) as well as OA cartilage samples (n=20) were evaluated using Q-PCR. (B) Chondrocytes were treated with 5 ng/ml IL-1β for 0, 3, 6, 12, or 24 hours. The miR-27a expression was assessed via Q-PCR, and normalization to the levels of GAPDH. The results are described as the mean ± SD. *P < 0.05, **P < 0.01 vs. indicated group.