Research Paper Volume 12, Issue 13 pp 12750—12770

Navitoclax (ABT263) reduces inflammation and promotes chondrogenic phenotype by clearing senescent osteoarthritic chondrocytes in osteoarthritis


Figure 3. The presence of senescent human chondrocytes (SnCs) in adjacent normal and advanced osteoarthritic articular cartilage. (A) Representative images of HMGB1-positive non-SnCs (brown staining at red arrows, scale bars, 100 μm) by immunohistochemistry and SA-β-gal-positive SnCs expression on OA articular cartilage, OA chondrocytes (P0) and adjacent normal cartilage. (B) The statistical analysis of the percentage of SA-β-gal and HMGB1 positive cells from three independent experiments. Scale bar: 100 μm.