Research Paper Volume 12, Issue 11 pp 10642—10662

Epigenome-wide gene–age interaction analysis reveals reversed effects of PRODH DNA methylation on survival between young and elderly early-stage NSCLC patients


Figure 2. DNA methylation and age interaction on survival of lung adenocarcinoma (LUAD) patients. (A) Hazard ratio (HR) of cg14326354PRODH 5% per decrement of methylation level among different aged patients. The 95% confidence interval (95% CI) band of HR for patients aged <57 or >65 years is statistically significant. Top histogram shows distribution of age. (B) Forest plots of HR of cg14326354PRODH 5% per decrement of methylation level in young and elderly LUAD patients, categorized based on boundary of 95% CI (BoCI) and 1956 United Nations standard. (C) Kaplan-Meier survival curves of low and high methylation groups (categorized by median value) among young and elderly LUAD patients defined using BoCI standard. Pheterogeneity was used to evaluate heterogeneity of HRs across age groups.