Research Paper Volume 12, Issue 11 pp 11025—11041

LncRNA ADAMTS9-AS2 inhibits gastric cancer (GC) development and sensitizes chemoresistant GC cells to cisplatin by regulating miR-223-3p/NLRP3 axis


Figure 8. The graphical abstract of this study. Briefly, long-term cisplatin stimulation inhibited LncRNA ADAMTS9 and increased miR-223-3p levels in GC cells, which inhibited pyroptotic cell death by inactivating NLRP3 inflammasome. Therefore, the GC cells with aberrant gene expressions were resistant to cisplatin.