Research Paper Volume 12, Issue 11 pp 10194—10210

Influences of TP53 and the anti-aging DDR1 receptor in controlling Raf/MEK/ERK and PI3K/Akt expression and chemotherapeutic drug sensitivity in prostate cancer cell lines

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Figure 3. DDR1 and TP53 expression in four prostate cancer cell lines. Panel (A) The levels of DDR1, TP53 and β-actin expression were determined in 22Rv-1, LNCaP, DU145 and PC3 cells. Panel (B) The levels of DDR1, P-Akt and T-Akt were determined in LNCaP, LNCaP + DN-TP53, 22Rv-1 and 22Rv-1 + DN-TP53 cells. Panel (C) The levels of P-ERK1,2 were determined in LNCaP, LNCaP + DN-TP53, 22Rv-1 and 22Rv-1 + DN-TP53 cells. The fold values shown in white numbers and letters are presented as averages of 3 densitometric readings. Only similar cell lines are compared. ND = none detected.