Research Paper Volume 12, Issue 18 pp 17921—17929

circKIF4A sponges miR-127 to promote ovarian cancer progression


Figure 1. Knockdown of circKIF4A inhibits ovarian cancer proliferation and invasion in vitro. (A) The expression of circKIF4A in ovarian cancer tissues (Tumor) and normal adjacent tissues (Normal). (B) circKIF4A was successfully knocked down by siRNA. (C) CCK-8 assay was performed to detect cell proliferation. (D) BrDU immunostaining of ovarian cancer cells transfected with si-NC of si-circKIF4A. (E) Transwell assay was performed to assess cell invasive ability (left) and the number of invasive cells was quantified by ImageJ (right). **P < 0.01