Research Paper Volume 12, Issue 13 pp 13023—13037

The Gαh/phospholipase C-δ1 interaction promotes autophagosome degradation by activating the Akt/mTORC1 pathway in metastatic triple-negative breast cancer


Figure 6. The signature of the combined Gαh upregulation and low levels of autophagy activity increases the likelihood of lung metastasis in ER(-) breast cancer patients. (A) Transcriptional profiling of the autophagy-related gene set in the groups shown in Figure1A. The statistical significance was analyzed by Student’s t-test. (B) Correlation of the expression levels of Gαh mRNA and the autophagy-related gene set in the stratified groups. (C and D) Results from the Kaplan-Meier analyses for the transcriptional level of the autophagy-related gene set alone (G) or combined with the mRNA level of Gαh (D) against ER(-) breast cancer patients from the GSE5327 data set.