Research Paper Volume 12, Issue 13 pp 13187—13205

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway


Figure 1. EA pretreatment ameliorated neurological deficits and reduced infarct volume in rats with CIR injury. (A) The schematic diagram illustrating the chronological events of experiments. (B) Rat schematic (a) and human schematic (b) showing the location of the EA acupoints selected in the present study. GV20 stands for “Baihui”, which is located at the right midpoint of the parietal bone. LI11 stands for “Quchi”, which is located in the depression lateral to the anterior aspect of the radial proximal elbow. ST36 stands for “Zusanli”, which is located in the posterolateral side of the knee joint, approximately 5 mm below the capitula fibula. (C) Neurological deficit scores (n=14). Neurological deficits were evaluated by Longa’s score. (D) Images of brain sections by TTC staining. (E) The ratio of infarct volume. Data were presented as mean ± SEM (n=3). **P<0.01, vs. sham group; ##P<0.01, vs. I/R group; &&P<0.01, vs. I/R + EA group.