Priority Research Paper Volume 12, Issue 12 pp 11185—11199

The mitochondrial derived peptide humanin is a regulator of lifespan and healthspan

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Figure 1. Humanin overexpression is sufficient to increase lifespan in C. elegans. HN overexpression significantly increased lifespan in worms (average lifespan of 19.0 days) compared to wild-type/N2 (average lifespan 17.7 days) (A). This increase in lifespan was dependent on daf-16 as daf-16(mu86) mutants did not have any increase in lifespan when crossed with the humanin-tg strain (average lifespan 15.5 days vs 16.1 days respectively) (p < 0.2) (B). Hn-tg worms also had a significant decrease in body length, body fat, and reproductive output (CE). *indicates p<.05.