Research Paper Volume 12, Issue 18 pp 17976—17989

Prothrombotic effects of high uric acid in mice via activation of MEF2C-dependent NF-κB pathway by upregulating let-7c


Figure 8. The mechanism of HUA in thrombosis with involvement of let-7c and MEF2C. HUA repressed MEF2C to activate NF-κB pathway by upregulating let-7c, ultimately causing blood coagulation and thrombosis.