Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis

Zhiyu Yang; Qiaoyun Xia; Di Lu; Han Yue; Jianmin Zhang; Yalong Li; Bingyong Zhang; Xiuling Li; Mingbo Cao

doi:doi:10.18632/aging.103962

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Research Paper Volume 12, Issue 21 pp 21660—21673

Human mesenchymal stem cells treatment improved hepatic lesions and reversed gut microbiome disorder in non-alcoholic steatohepatitis

Figure 4. Human mesenchymal stem cells reversed the microbiome disorder induced by MCD diet. (A–C) The most abundant taxa at the family (A), genus (B), and species (C) levels. (D) LEfSe cladogram representing taxa enriched in the chow, MCD and MCD + hMSCs groups. Rings from inside out represented taxonomic levels from phylum to genus levels. Sizes of circles indicate the relative abundance of the taxa. (E) Discriminative biomarkers with an LDA score > 4.0.