Research Paper Volume 13, Issue 7 pp 10058—10074

Gut microbiota from mice with cerebral ischemia-reperfusion injury affects the brain in healthy mice

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Figure 4. Effect of BCCAO microbiota on mice behavior. (A) Time spent in the center (left), corner (middle), and periphery (right) of the open field test. (B) The nest-building scores of micecontrol and miceBCCAO. (C) The latency in the training and testing phases for micecontrol and miceBCCAO in the Morris water maze test. (D) The preferential index (%) after 1 hour (left) and 24 hours (right) of training in the testing phase of the novel object recognition test. * denotes P < 0.05, ** denotes P < 0.01 and *** denotes P < 0.001 compared with control mice using unpaired Student`s t-tests or a two-way repeated-measures ANOVA with post-hoc Tukey multiple comparisons test. All values are expressed as means ± S.D, n=15.