Research Paper Volume 13, Issue 7 pp 10659—10671

Anti-inflammatory effect of resveratrol attenuates the severity of diabetic neuropathy by activating the Nrf2 pathway

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Figure 3. (A, B) Quantification by Western blot analysis showed that the expression of Nrf2 increased in STZ+Resveratrol mice at 12 weeks after STZ injection, compared with the never from STZ+Vehicle mice (n = 3 nerves for each group, data are represented as the mean ± SEM). (C, D) Immunofluorescence in longitudinal sections of STZ+Vehicle and STZ+Resveratrol sciatic nerves for Nrf2 (green) at 12 weeks after STZ injection. Nrf2 and MBP was increased in STZ+Resveratrol. (n = 3 nerves for each group, data are represented as the mean ± SEM).