Research Paper Volume 13, Issue 15 pp 19475—19485

FK506 binding protein 10: a key actor of collagen crosslinking in clear cell renal cell carcinoma

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Figure 5. Gene Ontology analysis reports FKBP10 and its correlated genes are densely involved in collagen synthesis. (A) Molecular function analysis of FKBP10 in ccRCC: collagen binding (GO:0005518), extracellular matrix structural constituent conferring tensile strength (GO:0030020), cis-trans isomerase activity (GO:0016859). (B) Biological process analysis of FKBP10 in ccRCC: collagen fibril organization (GO:0030199), extracellular matrix organization (GO:0030198), peptidyl-proline modification (GO:0018208), peptidyl-lysine hydroxylation (GO:0017185), collagen metabolic process (GO:0032963). (C) Cellular component analysis of FKBP10 in ccRCC:: endoplasmic reticulum lumen (GO:0005788), endoplasmic reticulum (GO:0005783), collagen type I trimer (G:0005584), collagen trimer (GO:0005581), fibrillar collagen trimer (GO:0005583), banded collagen fibril (GO:0098643), complex of collagen trimers (GO:0098644).