Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Xiang-Shu Cheng; Fang-Xiao Shi; Kun-Peng Zhao; Wang Lin; Xiao-Ying Li; Jun Zhang; Yao-Yao Bu; Rui Zhu; Xiao-Hong Li; Dong-Xiao Duan; Xin-Ying Ji; Jian-She Wei; Jian-Zhi Wang; Jin Du; Xin-Wen Zhou

doi:doi:10.18632/aging.203634

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Research Paper Volume 13, Issue 20 pp 23620—23636

Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 in AMPK activity-dependent manner

Figure 8. Schematic representation of Nmnat2 attenuating amyloidogenesis. Nmnat2 attenuates amyloidogenesis and up-regulates ADAM10 by increasing NAD⁺/NADH ratio in AMPK activity-dependent manner.