Research Paper Volume 14, Issue 22 pp 9210—9220

Resident intruder paradigm-induced PMDD rat model of premenstrual irritability: behavioral phenotypes, drug intervention, and biomarkers

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Figure 4. Changes in neurotransmitters in serum and brain of rats at various stages of the estrous cycle. R represents the acceptance period; NR represents the non-acceptance period, (4-1) displays the change of 5-TH content, (4-2) shows the change of NE content, and (4-3) demonstrates the change of GABA content, *p < 0.05 vs. control, **p < 0.01 vs. control, ***,#p < 0.05 vs. model; ##p < 0.01 vs. model, ##p < 0.001 vs. model.