Research Paper Volume 15, Issue 5 pp 1445—1474
Identification of GNG7 as a novel biomarker and potential therapeutic target for gastric cancer via bioinformatic analysis and in vitro experiments
Figure 2. Enrichment and module analyses of differentially expressed genes (DEGs). (A) GO enrichment analysis of the upregulated DEGs. (B) GO enrichment analysis of the downregulated DEGs. (C) KEGG pathway enrichment analysis of the up- and downregulated DEGs. (D–F) Top three modules of the PPI network from the upregulated DEGs (the color intensity of circles represents the connectivity degree of DEGs). (G–I) Top three modules of the PPI network from the downregulated DEGs (the color intensity of circles represents the connectivity degree of DEGs). (J, K) Three algorithms to screen the up- (J) and downregulated candidate hub genes (K) using the Venn diagram. Degree, node connect degree; DEGs, differentially expressed genes; GO, Gene Ontology; KEGG, Kyoto Encyclopedia of Genes and Genomes; MCC, maximal clique centrality; MNC, maximal neighborhood component; and PPI, protein–protein interaction.