Research Paper Volume 15, Issue 20 pp 10938—10971

Figure 2. The flow chart of study design. We categorized the Framingham Heart Study Offspring and Third Generation participants into three age groups: young (24–44 years, n = 690), middle-aged (45–64 years, n = 1866), older (65–94 years, n = 1267). We conducted association analyses of long-term average and cross-sectional alcohol consumption with EAA metrics in each age group. We used the pooled sample to estimate to what extent GAA and PAA mediates the association between alcohol consumption and hypertension.