Research Paper Volume 16, Issue 2 pp 1002—1020
Epigenetic drift underlies epigenetic clock signals, but displays distinct responses to lifespan interventions, development, and cellular dedifferentiation
Figure 4. Epigenetic disorder is influenced by lifespan extending manipulations. The effect of caloric restriction in C57BL/6 mice on (A) epigenetic age predictions from each data type and (B) age-adjusted global disorder. The effect of caloric restriction in B6D2F1 mice on (C) epigenetic age predictions from each data type and (D) age-adjusted global disorder. Comparison of Snell dwarf and control mice on (E) epigenetic age predictions from each data type and (F) age-adjusted global disorder. The effect of growth hormone receptor knock-out (GHRKO) on (G) epigenetic age predictions from each data type and (H) age-adjusted global disorder. All plots show median, upper, and lower quartiles, and maximum and minimum. Outliers beyond 1.5 interquartile range are plotted.