<i>Portulaca oleracea</i> L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis

Liping Xia; Mo Yang; Yan Liu

doi:doi:10.18632/aging.205608

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Research Paper Volume 16, Issue 6 pp 5108—5122

Portulaca oleracea L. polysaccharide inhibits ovarian cancer via inducing ACSL4-dependent ferroptosis

Figure 4. POL increased ACSL4 expression in a concentration gradient-dependent manner. JC-1 analysis showed that POL decreased MMP in SKOV3 (A) and Hey (B) cells (20×). FerroOrange staining showed that POL increased Fe²⁺ levels in SKOV3 (C) and Hey (D) cells (20×). Western blot assay revealed that POL increased the protein expression level of ACSL4 in SKOV3 (E) and Hey (F) in a concentration gradient-dependent manner. ^**P < 0.01, ^***p < 0.001 vs. Con.