Research Paper Volume 16, Issue 6 pp 5264—5287
COP9 signalosome complex is a prognostic biomarker and corresponds with immune infiltration in hepatocellular carcinoma
Figure 11. Role of COPS6 and COPS9 in the proliferation, migration, invasion, and cell cycle progression regulation of HCC cells. (A) Colony formation assays showing the role of COPS6 and COPS9 on HepG2 and SK-HEP-1 cell proliferation. (B) Cell viability of HepG2 and SK-HEP-1 cell lines were determined by CCK-8 assays. (C) The effects of COPS6 and COPS9 on cell migration and invasion were determined by transwell assays in Hep G2 and SK-HEP-1 cell lines. (D) The relative expression levels of cyclin B1, CDK4, p18, and p21 were examined by Western blotting in Hep G2 and SK-HEP-1 cells. *p < 0.05, **p < 0.01, ***p < 0.001.