Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Yuyi Yuan; Shuangjiao Deng; Jia Yang; Zhexing Shou; Chunzhu Wei; Lijuan Zhang; Feng Zhu; Fei Gao; Xingxing Liu; Yujin Liu; Qianyun Chen; Heng Fan

doi:doi:10.18632/aging.205651

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Research Paper Volume 16, Issue 6 pp 5336—5353

Antagomir of miR-31-5p modulates macrophage polarization via the AMPK/SIRT1/NLRP3 signaling pathway to protect against DSS-induced colitis in mice

Figure 9. Antagomir of miR-31-5p can activate AMPK/SIRT1-dependent signaling to inhibit NLRP3 inflammasome in macrophages and promote the transformation of M1-type macrophages to M2-type macrophages to improve inflammatory response in colitis.