Research Paper Volume 16, Issue 6 pp 5526—5544
Cinobufotalin regulates the USP36/c-Myc axis to suppress malignant phenotypes of colon cancer cells in vitro and in vivo
Figure 1. USP36 is highly expressed in colon cancer and further up-regulated in Oxa-resistant colon cancer cells. (A) The expression profile of USP36 between COAD and normal samples. (B) The expression profile of USP36 in different stages of COAD patients. (C) The analysis between OS and USP36 expression in COAD patients. (D) The analysis between DFS and USP36 expression in COAD patients. (E) The mRNA (top) and protein (button) expression levels of USP36 in NCM460 cells and colon cancer cells (SW480, HCT116, Lovo, and CaCO2). (F) The mRNA (top) and protein (button) expression levels of USP36 between Oxa-resistant and the parental colon cancer cells. *p < 0.05, **p < 0.01, and ***p < 0.005.