Research Paper Volume 16, Issue 6 pp 5567—5580
CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN
Figure 1. DOX induced myocardial senescence and decreased expression of CRIF1 in mice myocardial tissues. (A) The expression of myocardial injury-related enzymes LDH and CK-MB in serum was detected by biochemical kits. (B) RT-qPCR detected the expression of p27, p21, and p16 in myocardial tissues. (C) Western blot detected the expression of CRIF1 in myocardial tissues. ***P<0.001 vs Control.