Research Paper Volume 16, Issue 6 pp 5567—5580
CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN
Figure 4. CRIF1 overexpression alleviated DOX-induced myocardial mitochondrial dysfunction. (A) The changes of MMP were detected by JC-1 staining. (B) DCFH-DA staining was used to detect ROS levels. (C) The levels of MDA, GSH and CAT in myocardial tissues were detected by biochemical kits. ***P<0.001 vs Control; ##P<0.01, ###P<0.001 vs DOX+AAV-NC.