Research Paper Volume 16, Issue 6 pp 5567—5580

CRIF1 attenuates doxorubicin-mediated mitochondrial dysfunction and myocardial senescence via regulating PXDN

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Figure 5. The expression of CRIF1 was decreased in DOX-induced AC16 cells. (A) The cell activity was detected by CCK8. (B) RT-qPCR detected the expression of p27, p21, and p16 in AC16 cells. (C) The protein expression of CRIF1 was examined by western blot. *P<0.05, **P<0.01, ***P<0.001 vs Control.