Research Paper Volume 16, Issue 6 pp 5581—5600
Correlation between S100A7 and immune characteristics, methylation, tumor stemness and tumor heterogeneity in pan-cancer and its role in chemotherapy resistance in breast cancer
Figure 7. Correlation between S100A7 expression and immune infiltration as well as immune checkpoints pan-cancer, and the relationship between S100A7 expression and immune activity scores in breast cancer. (A) Correlation between S100A7 expression and immune infiltration pan-cancer. Correlation between S100A7 expression and the ESTIMATE score (B), immune score (C), and stromal score (D) in breast cancer. (E) Relationship between S100A7 expression and immune activity score in breast cancer. STEP1: Release of cancer cell antigens; STEP2: Cancer antigen presentation; STEP3: Priming and activation; STEP4: Trafficking of cells to tumors; STEP5: Infiltration of immune cells into tumors; STEP6: Recognition of cancer cells by T cells; STEP7: Killing of cancer cells. (F) Correlation between S100A7 expression and immune checkpoints pan-cancer. The expression of genes related to inhibitors (G) and stimulators (H) of immune checkpoints in the two groups based on the median S100A7 expression in breast cancer. “ns” represents not significant. *P < 0.05; **P < 0.01; ***P < 0.001.