Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Yunfang Yang; Changjiang Li; Sijin Yang; Zhuo Zhang; Xue Bai; Hongmei Tang; Jiang Huang

doi:doi:10.18632/aging.205678

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Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Figure 2. Cepharanthine (CEP) prevented the increase in blood-brain barrier (BBB) permeability in MCAO mice model. Blood-brain barrier permeability was measured by diffusion of sodium fluorescein assay (**, P<0.01 vs. vehicle group; ##, P<0.01 vs. MCAO group).