Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Yunfang Yang; Changjiang Li; Sijin Yang; Zhuo Zhang; Xue Bai; Hongmei Tang; Jiang Huang

doi:doi:10.18632/aging.205678

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Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Figure 6. Cepharanthine (CEP) attenuated hypoxia/reperfusion-induced aggravation of endothelial permeability in brain bEND.3 endothelial cells. (A) Endothelial permeability was measured using FITC-dextran; (B) The trans-endothelial electrical resistance (TEER) (**, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. H/R group).