Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Yunfang Yang; Changjiang Li; Sijin Yang; Zhuo Zhang; Xue Bai; Hongmei Tang; Jiang Huang

doi:doi:10.18632/aging.205678

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Research Paper Volume 16, Issue 7 pp 5905—5915

Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway

Figure 8. Cepharanthine (CEP) reduced the expression of VEGF-A and VEGFR2 in brain bEND.3 endothelial cells. (A) mRNA of VEGF-A and VEGFR2; (B) Protein of VEGF-A and VEGFR2 (**, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. H/R group).