Research Paper Volume 16, Issue 7 pp 5916—5928
Downregulating miRNA-199a-5p exacerbates fluorouracil-induced cardiotoxicity by activating the ATF6 signaling pathway
Figure 7. 5-FU causes the decreased expression of miRNA-199a-5p and activated the ATF6 and PERK in endoplasmic reticulum stress, which led to the up regulation of CHOP expression.