Research Paper Volume 16, Issue 7 pp 5987—6007

Identification and validation of the biomarkers related to ferroptosis in calcium oxalate nephrolithiasis

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Figure 2. Screening the hub DEFERGs via WGCNA and machine learning. (A) The power value β, set at 8, is indicated by the red line, ensuring a robust R2 > 0.9. (B) The clustering dendrogram illustrates the amalgamation of gene co-expression modules, with each color signifying a distinct module. (C) The heatmap displays the correlation between modules and clinical traits, featuring correlation coefficients and corresponding P-values at the intersections of rows and columns. (D) The Venn plot illustrates the overlapping genes between DEFERGs and those found in the nephrolithiasis-related module (turquoise). (E, F) LASSO regression of the 22 intersected DEFERGs. (G) Coefficients between the two hub DEFERGs and the clinical portraits.