Research Paper Volume 16, Issue 7 pp 6135—6146
Lifibrate attenuates blood-brain barrier damage following ischemic stroke via the MLCK/p-MLC/ZO-1 axis
Figure 4. Lifibrate mitigated oxygen-glucose deprivation/reperfusion (OGD/R)- induced insults in bEnd.3 brain microvascular endothelial cells. Cells were exposed to hypoxic conditions for 6 h, followed by exposure to reperfusion media for 24 h in the presence or absence of Lifibrate (3, 6 μM). (A) Cell viability was determined by MTT assay; (B) Release of LDH (n=10, **, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. OGD/R group).