Research Paper Volume 16, Issue 7 pp 6135—6146

Figure 5. Lifibrate attenuated OGD/R-induced aggravation in brain endothelial monolayer permeability in bEnd.3 brain microvascular endothelial cells. Cells were exposed to hypoxic conditions for 6 h, followed by exposure to reperfusion media for 24 h in the presence or absence of Lifibrate (3, 6 μM). (A) Brain endothelial permeability was assessed by FITC-dextran permeation; (B) TEER on the endothelial monolayer was measured (n=6, **, P<0.01 vs. vehicle group; #, ##, P<0.05, 0.01 vs. OGD/R group).