Research Paper Volume 16, Issue 7 pp 6147—6162

Figure 4. Effect of Poria cocos polysaccharides (PCPs) on inflammatory factors in alcoholic liver disease (ALD) rats. After the intervention of PCP (100 mg/kg), compared with the ALD group and the ML385 group, the LPS, IL-1β, IL-6, and TNF-α levels in rats were significantly increased (P < 0.01). After intervention with PCP, Fer-1, LPS, IL-1β, IL-6, and TNF-α levels in rats were significantly reduced (P < 0.01), indicating that PCP and ferroptosis inhibitors can reduce the expression of inflammatory factors. The reported values are presented as mean ± SD, n = 8. ^*P < 0.05, ^***P < 0.01, compared with the control group; ^#P < 0.05, ^###P < 0.01, compared with the ALD group; ^xP < 0.05, ^xxxP< 0.01, compared with the ML385 group.