Research Paper Volume 16, Issue 7 pp 5829—5855

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

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Figure 4. Compound effects on CeleST composite swim scores. The effect of adult exposure to NP1, propyl gallate, or resveratrol on overall swimming ability with age in (A) three C. elegans strains (N2, JU775, MY16), and (B) three C. briggsae strains (AF16, JU1348, HK104). Swimming assays were run on days 5, 9, and 12 of adulthood. Bars represent the mean +/− the standard error of the mean. Adjusted swimming score values were normalized to the strain mean value. Two biological replicates were completed at each of the three CITP testing sites. Asterisks represent p-values from the linear mixed model such that ****p < 0.0001, ***p < 0.001, **p < 0.01, and *p < 0.05.