Research Paper Volume 16, Issue 7 pp 5829—5855

The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background

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Figure 5. Relative compound effects on health vs. lifespan. Comparing the effect of (A) NP1, (B) propyl gallate, and (C) resveratrol on manual lifespan versus healthspan measures in two Caenorhabditis species (lifespan data from reference [34]). The lifespan effect is the fold change in median lifespan for a strain compared to its untreated control. For health, the relative rate of decline for each strain and compound is compared to the rate of decline for the control. Positive numbers would reflect either lifespan extension or slowed decline in the health measure, while negative numbers would reflect shortened lifespan and accelerated decline in the health measure. Each point represents a strain and health measure combination. Dotted line surrounds expanded box.