Online ISSN: 1945-4589
The cover features Figure 3 " Analysis of retrotransposons in somatic cells of aging dog“ from Fleyshman et al.

Volume 13, Issue 18

30 September, 2021
pp 21808—22624

About the Cover

The cover features Figure 3 " Analysis of retrotransposons in somatic cells of aging dog“ from Fleyshman et al.


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Editorials

Higher DNA repair in mitochondria of long-lived species

Gustavo Barja,
https://doi.org/10.18632/aging.203595 pp 21808—21809
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Does chronic jet lag increase risk of cancer?

Suliman Khan, Mengzhou Xue, V. Wee Yong,
https://doi.org/10.18632/aging.203596 pp 21810—21811
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SERPINA3 in glioblastoma and Alzheimer’s disease

Emily S. Norton, Sandro Da Mesquita, Hugo Guerrero-Cazares,
https://doi.org/10.18632/aging.203603 pp 21812—21813
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Research Perspective

Development of infrastructure for a systemic multidisciplinary approach to study aging in retired sled dogs

Daria I. Fleyshman, Joseph J. Wakshlag, Heather J. Huson, John P. Loftus, Natasha J. Olby, Leonid Brodsky, Andrei V. Gudkov, Ekaterina L. Andrianova,
https://doi.org/10.18632/aging.203600 pp 21814—21837
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Priority Research Paper

COVID-19
SARS-CoV-2 causes senescence in human cells and exacerbates the senescence-associated secretory phenotype through TLR-3

Utkarsh Tripathi, Rayhane Nchioua, Larissa G. P. Langhi Prata, Yi Zhu, Erin O. Wissler Gerdes, Nino Giorgadze, Tamar Pirtskhalava, Erik Parker, Ailing Xue, Jair Machado Espindola-Netto, Steffen Stenger, Paul D. Robbins, Laura J. Niedernhofer, Stephanie L. Dickinson, David B. Allison, Frank Kirchhoff, Konstantin Maria Johannes Sparrer, Tamar Tchkonia, James L. Kirkland,
https://doi.org/10.18632/aging.203560 pp 21838—21854
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Research Papers

COVID-19
Centenarians exposed to the Spanish flu in their early life better survived to COVID-19

Michel Poulain, Dany Chambre, Giovanni Mario Pes,
https://doi.org/10.18632/aging.203577 pp 21855—21865
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COVID-19
Efficacy and safety of current medications for treating severe and non-severe COVID-19 patients: an updated network meta-analysis of randomized placebo-controlled trials

Qinglin Cheng, Junfang Chen, Qingjun Jia, Zijian Fang, Gang Zhao,
https://doi.org/10.18632/aging.203522 pp 21866—21902
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COVID-19
Comparison of the clinical characteristics and mortalities of severe COVID-19 patients between pre- and post-menopause women and age-matched men

Danyong Liu, Han-Lin Ding, Yao Chen, De-Hong Chen, Changming Yang, Liu-Ming Yang, Jessica Aijia Liu, Liangqing Zhang, Zhong-Yuan Xia, Xi-He Zhang, Shaoqing Lei, Zhengyuan Xia,
https://doi.org/10.18632/aging.203532 pp 21903—21913
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Metformin-induced chemosensitization to cisplatin depends on P53 status and is inhibited by Jarid1b overexpression in non-small cell lung cancer cells

Tharcisio Citrangulo Tortelli Jr, Rodrigo Esaki Tamura, Mara de Souza Junqueira, Janio da Silva Mororó, Silvina Odete Bustos, Renato Jose Mendonça Natalino, Shonagh Russell, Laurent Désaubry, Bryan Eric Strauss, Roger Chammas,
https://doi.org/10.18632/aging.203528 pp 21914—21940
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Synergic association of diabetes mellitus and chronic kidney disease with muscle loss and cachexia: results of a 16-year longitudinal follow-up of a community-based prospective cohort study

Changhyun Lee, Hyun Jung Kim, Tae Ik Chang, Ea Wha Kang, Young Su Joo, Hyung Woo Kim, Jung Tak Park, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han,
https://doi.org/10.18632/aging.203539 pp 21941—21961
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Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice

Phyu Phyu Khin, Yeonhee Hong, MyeongHoon Yeon, Dae Ho Lee, Jong Han Lee, Hee-Sook Jun,
https://doi.org/10.18632/aging.203546 pp 21962—21974
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Thymus hirtus sp. algeriensis Boiss. and Reut. volatile oil enhances TRAIL/Apo2L induced apoptosis and inhibits colon carcinogenesis through upregulation of death receptor pathway

Fatma Guesmi, Sahdeo Prasad, Manel Ben Ali, Ismail A. Ismail, Ahmed Landoulsi,
https://doi.org/10.18632/aging.203552 pp 21975—21990
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Identification of colorectal cancer associated biomarkers: an integrated analysis of miRNA expression

André Fonseca, Sara Ventura Ramalhete, André Mestre, Ricardo Pires das Neves, Ana Marreiros, Pedro Castelo-Branco, Vânia Palma Roberto,
https://doi.org/10.18632/aging.203556 pp 21991—22029
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Cerebral small vessel disease, systemic vascular characteristics and potential therapeutic targets

Salim Elyas, Damilola Adingupu, Kunihiko Aizawa, Francesco Casanova, Kim Gooding, Jonathan Fulford, Dave Mawson, Phillip E. Gates, Angela C. Shore, David Strain,
https://doi.org/10.18632/aging.203557 pp 22030—22039
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A2E-induced inflammation and angiogenesis in RPE cells in vitro are modulated by PPAR-α, -β/δ, -γ, and RXR antagonists and by norbixin

Valérie Fontaine, Mylène Fournié, Elodie Monteiro, Thinhinane Boumedine, Christine Balducci, Louis Guibout, Mathilde Latil, José-Alain Sahel, Stanislas Veillet, Pierre J. Dilda, René Lafont, Serge Camelo,
https://doi.org/10.18632/aging.203558 pp 22040—22058
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Sex, rurality and socioeconomical status in Spanish centennial population (2017)

Pedro Fuentes, Sandra Amador, Ana Maria Lucas-Ochoa, Lorena Cuenca-Bermejo, Emiliano Fernández-Villalba, Valeria Raparelli, Colleen Norris, Alexandra Kautzky-Willer, Karolina Kublickiene, Louise Pilote, María Trinidad Herrero, the GOING-FWD Consortium,
https://doi.org/10.18632/aging.203563 pp 22059—22077
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The relationship between plasma free fatty acids, cognitive function and structural integrity of the brain in middle-aged healthy humans

Markus Herrmann, Sebastian Simstich, Günter Fauler, Edith Hofer, Eva Fritz-Petrin, Wolfgang Herrmann, Reinhold Schmidt,
https://doi.org/10.18632/aging.203573 pp 22078—22091
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Adulthood systemic inflammation accelerates the trajectory of age-related cognitive decline

Jolie Barter, Ashok Kumar, Linda Bean, Marissa Ciesla, Thomas C. Foster,
https://doi.org/10.18632/aging.203588 pp 22092—22108
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LHX9, a p53-binding protein, inhibits the progression of glioma by suppressing glycolysis

Xiangying Luo, Jianwei Ge, Tao Chen, Jinfang Liu, Ziyuan Liu, Changlong Bi, Song Lan,
https://doi.org/10.18632/aging.203436 pp 22109—22119
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Metformin inhibits hepatocellular carcinoma development by inducing apoptosis and pyroptosis through regulating FOXO3

Zetian Shen, Han Zhou, Aomei Li, Tiancong Wu, Xiaoqin Ji, Lei Guo, Xixu Zhu, Dagan Zhang, Xia He,
https://doi.org/10.18632/aging.203464 pp 22120—22133
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Rutin inhibited the advanced glycation end products-stimulated inflammatory response and extra-cellular matrix degeneration via targeting TRAF-6 and BCL-2 proteins in mouse model of osteoarthritis

Xiang Chen, Mingchuan Yu, Wei Xu, Linfeng Zou, Jing Ye, Yu Liu, Yuhong Xiao, Jun Luo,
https://doi.org/10.18632/aging.203470 pp 22134—22147
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Low expression of KIF20A suppresses cell proliferation, promotes chemosensitivity and is associated with better prognosis in HCC

Chuanxing Wu, Xiaosheng Qi, Zhengjun Qiu, Guilong Deng, Lin Zhong,
https://doi.org/10.18632/aging.203494 pp 22148—22163
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SLCO1B3 promotes colorectal cancer tumorigenesis and metastasis through STAT3

Lianghui Zhi, Lianmei Zhao, Xue Zhang, Wei Liu, Bo Gao, Feifei Wang, Xiaoran Wang, Guiying Wang,
https://doi.org/10.18632/aging.203502 pp 22164—22175
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Key genes affecting the progression of nasopharyngeal carcinoma identified by RNA-sequencing and bioinformatic analysis

Yihong Wang, Manyi Li, Yan Guo, Haiping Huang, Xuelin Dong, Yangguang Sun, Jisheng Liu,
https://doi.org/10.18632/aging.203521 pp 22176—22187
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Cx32 inhibits the autophagic effect of Nur77 in SH-SY5Y cells and rat brain with ischemic stroke

Fengfeng Ping, Chao Zhang, Xue Wang, Yan Wang, Danli Zhou, Jing Hu, Yanhua Chen, Jingjing Ling, Jia Zhou,
https://doi.org/10.18632/aging.203526 pp 22188—22207
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Involvement of c-Myc in low dose radiation-induced senescence enhanced migration and invasion of unirradiated cancer cells

Jyh-Der Leu, Chung-Yih Wang, Chia-Chien Lo, Min-Ying Lin, Chun-Yuan Chang, Wen-Chin Hung, Shi-Ting Lin, Bo-Shen Wang, Yi-Jang Lee,
https://doi.org/10.18632/aging.203527 pp 22208—22231
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High prevalence of thyroid carcinoma in patients with insulin resistance: a meta-analysis of case-control studies

Junyu Zhao, Qianping Zhang, Yupeng Yang, Jinming Yao, Lin Liao, Jianjun Dong,
https://doi.org/10.18632/aging.203529 pp 22232—22241
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miR-21 regulates ischemic neuronal injury via the p53/Bcl-2/Bax signaling pathway

Honglin Yan, Wenxian Huang, Jie Rao, Jingping Yuan,
https://doi.org/10.18632/aging.203530 pp 22242—22255
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Nucleotide variants in hepatitis B virus preS region predict the recurrence of hepatocellular carcinoma

Xi Chen, Minfeng Zhang, Nan Li, Rui Pu, Ting Wu, Yibo Ding, Peng Cai, Hongwei Zhang, Jun Zhao, Jianhua Yin, Guangwen Cao,
https://doi.org/10.18632/aging.203531 pp 22256—22275
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Improvement of cardiac function by mesenchymal stem cells derived extracellular vesicles through targeting miR-497/Smad7 axis

Min Chen, Jianfei Chen, Caiting Li, Ranjie Yu, Weiwen Chen, Cunrong Chen,
https://doi.org/10.18632/aging.203533 pp 22276—22285
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ASXL1 promotes adrenocortical carcinoma and is associated with chemoresistance to EDP regimen

Liang Wang, Yinfeng Lyu, Yuqing Li, Kunping Li, Hui Wen, Chenchen Feng, Ning Li,
https://doi.org/10.18632/aging.203534 pp 22286—22297
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AKR1B10 inhibits the proliferation and migration of gastric cancer via regulating epithelial-mesenchymal transition

Xinyu Shao, Jue Wu, Shunying Yu, Yuqing Zhou, Chunli Zhou,
https://doi.org/10.18632/aging.203538 pp 22298—22314
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High CTSL2 expression predicts poor prognosis in patients with lung adenocarcinoma

Junnian Song, Jindong Jiang, Na Wei, Zongsheng Duan, Gang Wang, Weiyun Pan,
https://doi.org/10.18632/aging.203540 pp 22315—22331
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METTL3-mediated m6A modification of KIF3C-mRNA promotes prostate cancer progression and is negatively regulated by miR-320d

Honggui Ma, Facai Zhang, Quliang Zhong, Jianquan Hou,
https://doi.org/10.18632/aging.203541 pp 22332—22344
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Identifying critical genes associated with aneurysmal subarachnoid hemorrhage by weighted gene co-expression network analysis

Zhizhong Yan, Qi Wu, Wei Cai, Haitao Xiang, Lili Wen, An Zhang, Yaonan Peng, Xin Zhang, Handong Wang,
https://doi.org/10.18632/aging.203542 pp 22345—22360
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Identification of clinical trait-related small RNA biomarkers with weighted gene co-expression network analysis for personalized medicine in endocervical adenocarcinoma

Zhiwen Shi, Xinyu Qu, Chenyan Guo, Lihong Zhang, Chuyue Peng, Zhu Xie, Keqin Hua, Junjun Qiu,
https://doi.org/10.18632/aging.203543 pp 22361—22374
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A new mechanism of POCD caused by sevoflurane in mice: cognitive impairment induced by cross-dysfunction of iron and glucose metabolism

Xing Ge, Yong Zuo, Jinhong Xie, Xincheng Li, Yan Li, Anand Thirupathi, Peng Yu, Guofen Gao, Changhao Zhou, Yanzhong Chang, Zhenhua Shi,
https://doi.org/10.18632/aging.203544 pp 22375—22389
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Deficiency of miR-29b2/c leads to accelerated aging and neuroprotection in MPTP-induced Parkinson’s disease mice

Xiaochen Bai, Xiaoshuang Zhang, Rong Fang, Jinghui Wang, Yuanyuan Ma, Zhaolin Liu, Hongtian Dong, Qing Li, Jingyu Ge, Mei Yu, Jian Fei, Ruilin Sun, Fang Huang,
https://doi.org/10.18632/aging.203545 pp 22390—22411
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Pim-2 kinase inhibits inflammation by suppressing the mTORC1 pathway in atherosclerosis

Minqi Liao, Feng Hu, Zhiqiang Qiu, Juan Li, Chahua Huang, Yan Xu, Xiaoshu Cheng,
https://doi.org/10.18632/aging.203547 pp 22412—22431
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Circular RNA Foxo3 enhances progression of ovarian carcinoma cells

Li Wang, Jing Chen, Chunhua Lu,
https://doi.org/10.18632/aging.203550 pp 22432—22443
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SUV39H2/KMT1B Inhibits the cardiomyocyte senescence phenotype by down-regulating BTG2/PC3

Kan Wang, Qiang Zhang Zhu, Xian Tao Ma, Cai Cheng,
https://doi.org/10.18632/aging.203551 pp 22444—22458
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miR-19b-3p relieves intervertebral disc degeneration through modulating PTEN/PI3K/Akt/mTOR signaling pathway

Yulin Zhao, Aimin Li,
https://doi.org/10.18632/aging.203553 pp 22459—22473
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Identification of genes and pathways leading to metastasis and poor prognosis in melanoma

Xin Zhang, Wandong Wang, Yun Wang, Guan Jiang,
https://doi.org/10.18632/aging.203554 pp 22474—22489
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Nesfatin-1 facilitates IL-1β production in osteoarthritis synovial fibroblasts by suppressing miR-204-5p synthesis through the AP-1 and NF-κB pathways

Kun-Tsan Lee, Bo-Cheng Chen, Shan-Chi Liu, Yen-You Lin, Chun-Hao Tsai, Chih-Yuan Ko, Chih-Hsin Tang, Kwong-Chung Tung,
https://doi.org/10.18632/aging.203559 pp 22490—22501
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Melatonin inhibits proliferation, migration, and invasion by inducing ROS-mediated apoptosis via suppression of the PI3K/Akt/mTOR signaling pathway in gallbladder cancer cells

Kunlun Chen, Pengfei Zhu, Wenhui Chen, Kai Luo, Xiao-Jing Shi, Wenlong Zhai,
https://doi.org/10.18632/aging.203561 pp 22502—22515
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miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis

Fang Li, Shan-Shan Li, Hui Chen, Jian-Zhi Zhao, Jie Hao, Jin-Ming Liu, Xiu-Guang Zu, Wei Cui,
https://doi.org/10.18632/aging.203562 pp 22516—22527
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Inhibition of FSTL3 abates the proliferation and metastasis of renal cell carcinoma via the GSK-3β/β-catenin signaling pathway

Fengfeng Sun, Peng Sun, Xiaofeng Yang, Liangliang Hu, Jianguo Gao, Tao Tian,
https://doi.org/10.18632/aging.203564 pp 22528—22543
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Glaucocalyxin B inhibits cartilage inflammatory injury in rheumatoid arthritis by regulating M1 polarization of synovial macrophages through NF-κB pathway

Chenyang Han, Yi Yang, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Li Guo, Caiqun Zhang, Qiao Ye,
https://doi.org/10.18632/aging.203567 pp 22544—22555
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MSCs enhances the protective effects of valsartan on attenuating the doxorubicin-induced myocardial injury via AngII/NOX/ROS/MAPK signaling pathway

Dong Cheng, Wencheng Tu, Libo Chen, Haoren Wang, Qinfu Wang, Hainiang Liu, Ning Zhu, Weiyi Fang, Qin Yu,
https://doi.org/10.18632/aging.203569 pp 22556—22570
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Helicobacter pylori infection and risk for developing dementia: an evidence-based meta-analysis of case-control and cohort studies

Nan-Yang Liu, Jia-Hui Sun, Xue-Fan Jiang, Hao Li,
https://doi.org/10.18632/aging.203571 pp 22571—22587
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GPR43 regulation of mitochondrial damage to alleviate inflammatory reaction in sepsis

Weiwei Zhang, Wusan Wang, Maodi Xu, Haitang Xie, Zhichen Pu,
https://doi.org/10.18632/aging.203572 pp 22588—22610
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Theory Article

Applying deductive reasoning and the principles of particle physics to aging research

Alibek Moldakozhayev, Albina Tskhay, Vadim N. Gladyshev,
https://doi.org/10.18632/aging.203555 pp 22611—22622
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Correction

Correction for: The role of serum growth hormone and insulin-like growth factor-1 in adult humans brain morphology

Taoyang Yuan, Jianyou Ying, Lu Jin, Chuzhong Li, Songbai Gui, Zhenye Li, Rui Wang, Zhentao Zuo, Yazhuo Zhang,
https://doi.org/10.18632/aging.203601 pp 22623—22624
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