Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

Volume 13, Issue 24

31 December, 2021
pp 25604—26200

About the Cover

The cover features Figure 2 "Regulatory network of vertebrate core CR genes, including their transcriptional, post-transcriptional, and post-translational interaction partners that constitute activating and inhibitory feedback loops" from Barth et al.

Explore This Issue

Editorial

Aging, light sensitivity and circadian health

Sarah L. Chellappa,

https://doi.org/10.18632/aging.203806 pp 25604—25606

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Priority Research Paper

Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss

Yuhei Uda, Vaibhav Saini, Christopher A. Petty, Majed Alshehri, Chao Shi, Jordan M. Spatz, Roberto Santos, Carly M. Newell, Tim Y. Huang, Alejandro Kochen, Ji W. Kim, Christodoulos K. Constantinou, Hiroaki Saito, Kathryn D. Held, Eric Hesse, Paola Divieti Pajevic,

https://doi.org/10.18632/aging.203808 pp 25607—25642

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Research Papers

Healthy memory aging - the benefits of regular daily activities increase with age

Olga Krakovska, Gregory J. Christie, Faranak Farzan, Andrew Sixsmith, Martin Ester, Sylvain Moreno,

https://doi.org/10.18632/aging.203753 pp 25643—25652

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Maternal adverse childhood experiences before pregnancy are associated with epigenetic aging changes in their children

Jamaji C. Nwanaji-Enwerem, Lars Van Der Laan, Katherine Kogut, Brenda Eskenazi, Nina Holland, Julianna Deardorff, Andres Cardenas,

https://doi.org/10.18632/aging.203776 pp 25653—25669

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Chronobiological activity of cysteinyl leukotriene receptor 1 during basal and induced autophagy in the ARPE-19 retinal pigment epithelial cell line

Andreas Koller, Julia Preishuber-Pflügl, Christian Runge, Anja-Maria Ladek, Susanne Maria Brunner, Ludwig Aigner, Herbert Reitsamer, Andrea Trost,

https://doi.org/10.18632/aging.203787 pp 25670—25693

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Age-dependent expression changes of circadian system-related genes reveal a potentially conserved link to aging

Emanuel Barth, Akash Srivastava, Diane Wengerodt, Milan Stojiljkovic, Hubertus Axer, Otto W. Witte, Alexandra Kretz, Manja Marz,

https://doi.org/10.18632/aging.203788 pp 25694—25716

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Calcification in Werner syndrome associated with lymphatic vessels aging

Hideyuki Ogata, Shinsuke Akita, Sanae Ikehara, Kazuhiko Azuma, Takashi Yamaguchi, Maihulan Maimaiti, Yoshiro Maezawa, Yoshitaka Kubota, Koutaro Yokote, Nobuyuki Mitsukawa, Yuzuru Ikehara,

https://doi.org/10.18632/aging.203789 pp 25717—25728

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Factors influencing serum neurofilament light chain levels in normal aging

Marisa Koini, Lukas Pirpamer, Edith Hofer, Arabella Buchmann, Daniela Pinter, Stefan Ropele, Christian Enzinger, Pascal Benkert, David Leppert, Jens Kuhle, Reinhold Schmidt, Michael Khalil,

https://doi.org/10.18632/aging.203790 pp 25729—25738

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Small molecules for cell reprogramming: a systems biology analysis

Anna Knyazer, Gabriela Bunu, Dmitri Toren, Teodora Bucaciuc Mracica, Yael Segev, Marina Wolfson, Khachik K. Muradian, Robi Tacutu, Vadim E. Fraifeld,

https://doi.org/10.18632/aging.203791 pp 25739—25762

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Retinal drusen in patients with chronic myeloproliferative blood cancers are associated with an increased proportion of senescent T cells and signs of an aging immune system

Charlotte Liisborg, Vibe Skov, Lasse Kjær, Hans Carl Hasselbalch, Torben Lykke Sørensen,

https://doi.org/10.18632/aging.203803 pp 25763—25777

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PKMYT1, exacerbating the progression of clear cell renal cell carcinoma, is implied as a biomarker for the diagnosis and prognosis

Juan Chen, Xiaoliang Hua, Heying Chen, Xiangmin Qiu, Haibing Xiao, Shengdong Ge, Chaozhao Liang, Qin Zhou,

https://doi.org/10.18632/aging.203759 pp 25778—25798

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DNA methylation of ARHGAP30 is negatively associated with ARHGAP30 expression in lung adenocarcinoma, which reduces tumor immunity and is detrimental to patient survival

Sheng Hu, Wenxiong Zhang, Jiayue Ye, Yang Zhang, Deyuan Zhang, Jinhua Peng, Dongliang Yu, Jianjun Xu, Yiping Wei,

https://doi.org/10.18632/aging.203762 pp 25799—25845

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The risk of distant metastases in patients with gynecologic cancers after surgery: a population-based study

Yi-Hsuan Hsiao, Pei-Ni Chen, Min-Chien Hsin, Po-Hui Wang, Jing-Yang Huang, Shun-Fa Yang,

https://doi.org/10.18632/aging.203773 pp 25846—25858

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Identification and functional analysis of lncRNAs and mRNAs between tumorigenesis and metastasis in CRC

Hongtao Liu, Yuan Tian, Jiaxi Li, Guoxia Zhang, Qun Liu, Min Yang, Longtao Yue, Qiwei Cao, Guihui Zhang, Yuxia Cheng, Na Kong, Lei Fang, Shoupeng Li, Qing Sun,

https://doi.org/10.18632/aging.203775 pp 25859—25885

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Structural, functional and molecular pathogenesis of pelvic organ prolapse in patient and Loxl1 deficient mice

Yu Li, Nanfang Nie, Lin Gong, Fangyuan Bao, Chengrui An, Hongxia Cai, Xudong Yao, Yanshan Liu, Chunbo Yang, Bingbing Wu, XiaoHui Zou,

https://doi.org/10.18632/aging.203777 pp 25886—25902

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METTL14 benefits the mesenchymal stem cells in patients with steroid-associated osteonecrosis of the femoral head by regulating the m6A level of PTPN6

Cheng Cheng, Haoping Zhang, Jia Zheng, Yi Jin, Donghui Wang, Zhipeng Dai,

https://doi.org/10.18632/aging.203778 pp 25903—25919

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LDH-A inhibitors as remedies to enhance the anticancer effects of PARP inhibitors in ovarian cancer cells

Jiangdong Xiang, Lina Zhou, Yinyan He, Sufang Wu,

https://doi.org/10.18632/aging.203780 pp 25920—25930

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NAD+ improved experimental autoimmune encephalomyelitis by regulating SIRT1 to inhibit PI3K/Akt/mTOR signaling pathway

Jinli Wang, Xueqin Song, Guojun Tan, Pengtao Sun, Li Guo, Ning Zhang, Jueqiong Wang, Bin Li,

https://doi.org/10.18632/aging.203781 pp 25931—25943

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Global, regional, and national burden of age-related hearing loss from 1990 to 2019

Jinyu Man, Hui Chen, Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Ming Lu,

https://doi.org/10.18632/aging.203782 pp 25944—25959

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A novel pyroptosis-related gene signature to predict outcomes in laryngeal squamous cell carcinoma

Chongchang Zhou, Guowen Zhan, Yangli Jin, Jianneng Chen, Zhisen Shen, Yi Shen, Hongxia Deng,

https://doi.org/10.18632/aging.203783 pp 25960—25979

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Identification of a competing endogenous RNA network related to immune signature in clear cell renal cell carcinoma

Yuke Zhang, Jiangwen Dai, Weifeng Huang, Qingsong Chen, Wei Chen, Qiying He, Feng Chen, Peng Zhang,

https://doi.org/10.18632/aging.203784 pp 25980—26002

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Network pharmacology reveals the potential mechanism of Baiying Qinghou decoction in treating laryngeal squamous cell carcinoma

Kun Gao, Yanan Zhu, Hui Wang, Xianwei Gong, Zhiyong Yue, Aiai Lv, Xuanchen Zhou,

https://doi.org/10.18632/aging.203786 pp 26003—26021

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LINC00839 knockdown restrains the metastatic behavior of nasopharyngeal carcinoma by sponging miR-454-3p

Feng Ying Zhang, Xia Li, Ting Ting Huang, Mei Ling Xiang, Lin Lin Sun, Zhao Lan Sun,

https://doi.org/10.18632/aging.203792 pp 26022—26033

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rTMS alleviates AD-induced cognitive impairment by inhibitng apoptosis in SAMP8 mouse

Zheng Bao, Li Bao, Na Han, Yueyun Hou, Fumin Feng,

https://doi.org/10.18632/aging.203796 pp 26034—26045

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An immune-related lncRNA risk coefficient model to predict the outcomes in clear cell renal cell carcinoma

Cheng Tang, GenYi Qu, Yong Xu, Guang Yang, Jiawei Wang, Maolin Xiang,

https://doi.org/10.18632/aging.203797 pp 26046—26062

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Tertiary lymphoid structure stratifies glioma into three distinct tumor subtypes

Xingwang Zhou, Wenyan Li, Jie Yang, Xiaolan Qi, Yimin Chen, Hua Yang, Liangzhao Chu,

https://doi.org/10.18632/aging.203798 pp 26063—26094

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Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors

Zhangming Wei, Yi Hu, Xiang He, Mengmeng Zhang, Xinyue Zhang, Yali Wang, Xiaoling Fang, Liping Li,

https://doi.org/10.18632/aging.203799 pp 26095—26117

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Tumor microenvironment characterization in esophageal cancer identifies prognostic relevant immune cell subtypes and gene signatures

Yuhong Zhang, Minqi Zhu, Junxian Mo, Lei Xian,

https://doi.org/10.18632/aging.203800 pp 26118—26136

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miR-545 promotes colorectal cancer by inhibiting transferring in the non-normal ferroptosis signaling

Sixin Zheng, Lingling Hu, Qingwen Song, Yuqiang Shan, Guang Yin, Hanzhang Zhu, Wencheng Kong, Chunhua Zhou,

https://doi.org/10.18632/aging.203801 pp 26137—26147

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Free fatty acids-induced neutrophil extracellular traps lead to dendritic cells activation and T cell differentiation in acute lung injury

Wei Chen, Hong Chen, Zhi-Tao Yang, En-Qiang Mao, Ying Chen, Er-Zhen Chen,

https://doi.org/10.18632/aging.203802 pp 26148—26160

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Coupling of serum CK20 and hyper-methylated CLIP4 as promising biomarker for colorectal cancer diagnosis: from bioinformatics screening to clinical validation

Zhongjian Liu, Hui Tang, Wen Zhang, Jinli Wang, Lilan Wan, Xisha Li, Yuping Ji, Na Kong, Yanfang Zhang, Jiangang Wang, Zhang Fan, Qiang Guo,

https://doi.org/10.18632/aging.203804 pp 26161—26179

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NAP1L1 promotes proliferation and chemoresistance in glioma by inducing CCND1/CDK4/CDK6 expression through its interaction with HDGF and activation of c-Jun

Zigui Chen, Yingying Xie, Hongcheng Luo, Ye Song, Tianshi Que, Rentong Hu, Huatuo Huang, Kunxiang Luo, Chuanyu Li, Chengjian Qin, Chuanhua Zheng, Weiyi Fang, Longyang Liu, Hao Long, Qisheng Luo,

https://doi.org/10.18632/aging.203805 pp 26180—26200

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