Featured Nobel Articles

Elizabeth Blackburn, a member of the Editorial Board of Aging, won the Nobel Prize in Physiology or Medicine 2009, while being a member of the board. Elizabeth Blackburn co-authored a paper published in the first (inaugural) issue of Aging.
Andrew V. Schally, Nobel Prize Laureate, published his paper in Aging.
Shinya Yamanaka won the Nobel Prize in Physiology and Medicine 2012. Shinya Yamanaka co-authored a paper published in Aging.

Volume 15, Issue 4

28 February, 2023
pp 882—1229

About the Cover

The cover features Figure 4 "Hypothetical interaction between telomere shortening and inflammation induced by IL-6 leading to early subjective depressive symptoms and cognitive complaints in relatively healthy elderly" from Han et al.

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Editorials

Impact of sarcopenic obesity on functional outcomes

Akio Shimizu, Tatsuro Inoue, Keisuke Maeda,

https://doi.org/10.18632/aging.204549 pp 882—883

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Studying lateralization changes in the aging brain

Sara Magalhães Ferreira, Koen Cuypers, Melina Hehl,

https://doi.org/10.18632/aging.204550 pp 884—886

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Cognition and driving in older adults: a complex relationship

Luis Eudave, María A. Pastor,

https://doi.org/10.18632/aging.204551 pp 887—888

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Cognitive aging and dementia prevention: the time for psychology?

David Bartrés-Faz, Cristina Solé-Padullés, Natalie L. Marchant,

https://doi.org/10.18632/aging.204562 pp 889—891

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Research Perspectives

Circulating levels of MOTS-c in patients with breast cancer treated with metformin

Elisabet Cuyàs, Sara Verdura, Begoña Martin-Castillo, Javier A. Menendez, METTEN study group,

https://doi.org/10.18632/aging.204423 pp 892—897

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The neuronal nucleus: a new battlefield in fight against neurodegeneration

Eftekhar Eftekharpour,

https://doi.org/10.18632/aging.204519 pp 898—904

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Review

Cellular senescence: when growth stimulation meets cell cycle arrest

Mikhail V. Blagosklonny,

https://doi.org/10.18632/aging.204543 pp 905—913

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Research Papers

Relationship between telomere shortening and early subjective depressive symptoms and cognitive complaints in older adults

Myung-Hoon Han, Eun-Hye Lee, Hyun-Hee Park, Seong Hye Choi, Seong-Ho Koh,

https://doi.org/10.18632/aging.204533 pp 914—931

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Isoform-specific effects of neuronal repression of the AMPK catalytic subunit on cognitive function in aged mice

Xueyan Zhou, Wenzhong Yang, Xin Wang, Tao Ma,

https://doi.org/10.18632/aging.204554 pp 932—946

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Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies

Ariel K. Frame, J. Wesley Robinson, Nader H. Mahmoudzadeh, Jason M. Tennessen, Anne F. Simon, Robert C. Cumming,

https://doi.org/10.18632/aging.204565 pp 947—981

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Identification of cellular heterogeneity and key signaling pathways associated with vascular remodeling and calcification in young and old primate aortas based on single-cell analysis

Yehu Yin, Congcong Huang, Zidi Wang, Pan Huang, Shanshan Qin,

https://doi.org/10.18632/aging.204442 pp 982—1003

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Systematic investigation of the mechanism of herbal medicines for the treatment of prostate cancer

Jinghui Wang, Ran Ding, Ting Ouyang, Honglei Gao, Hongxing Kan, Yan Li, Qiongying Hu, Yinfeng Yang,

https://doi.org/10.18632/aging.204516 pp 1004—1024

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Circ_0001052 promotes cardiac hypertrophy via elevating Hipk3

Mengyue Yang, Weichen Wang, Longlong Wang, Yuze Li,

https://doi.org/10.18632/aging.204521 pp 1025—1038

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RIOK3 promotes mTORC1 activation by facilitating SLC7A2-mediated arginine uptake in pancreatic ductal adenocarcinoma

Henan Qin, Rui Sun, Xin Guo, Lei Fang, Mengyuan Xu, Yibin Teng, Ning Zhen, Aman Wang, Jiwei Liu,

https://doi.org/10.18632/aging.204528 pp 1039—1051

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TIPE2 acts as a tumor suppressor and correlates with tumor microenvironment immunity in epithelial ovarian cancer

Shuai Xu, Xiaolin Gao, Jianqing Qiu, Fanzhen Hong, Fufeng Gao, Xia Wang, Shiqian Zhang,

https://doi.org/10.18632/aging.204529 pp 1052—1073

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An immune-related prognostic signature associated with immune landscape and therapeutic responses in gastric cancer

Jian-Rong Sun, Chen-Fan Kong, Xiang-Ke Qu, An-Tao Sun, Kun-Peng Zhao, Jin-Hui Sun,

https://doi.org/10.18632/aging.204534 pp 1074—1106

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Prognostic significance of epidermal growth factor receptor and programmed cell death-ligand 1 co-expression in esophageal squamous cell carcinoma

Guoxiang Jiang, Yandong Miao, Zhenbo Wang, Qi Zhang, Ping Zhou, Fang Zhang,

https://doi.org/10.18632/aging.204535 pp 1107—1129

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Effects of magnetically targeted iron oxide@polydopamine-labeled human umbilical cord mesenchymal stem cells in cerebral infarction in mice

Jun Yan, Te Liu, Yang Li, Jun Zhang, Bo Shi, Fuqiang Zhang, Xuejia Hou, Xiaowen Zhang, Wanxing Cui, Jing Li, Hua Yao, Xiuying Li, Yufei Gao, Jinlan Jiang,

https://doi.org/10.18632/aging.204540 pp 1130—1142

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Allopregnanolone-mediated GABAA-Rα4 function in amygdala and hippocampus of PMDD liver qi-invasion syndrome model rats

Ya Sun, Mingzhou Gao, Dongmei Gao, Dan Chen, Jieqiong Wang,

https://doi.org/10.18632/aging.204541 pp 1143—1157

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Comprehensive landscape of immune-based classifier related to early diagnosis and macrophage M1 in spinal cord injury

Zhao Zhang, Zhijie Zhu, Xuankang Wang, Dong Liu, Xincheng Liu, Zhenzhou Mi, Huiren Tao, Hongbin Fan,

https://doi.org/10.18632/aging.204548 pp 1158—1176

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A novel fatty-acid metabolism-based classification for triple negative breast cancer

Xia Yang, Wen Tang, Yongtao He, Huimin An, Jin Wang,

https://doi.org/10.18632/aging.204552 pp 1177—1198

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Prognostic performance of serum YKL-40 for one-year clinical outcomes in acute ischemic stroke

Guomei Shi, Minghao Li, Yan E, Meng Wang, Pengyu Gong, Xiaorong Wang, Jingye Lu, Weixiang Wu, Shouru Xue, Junshan Zhou, Rujuan Zhou,

https://doi.org/10.18632/aging.204553 pp 1199—1209

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Inhibition of apoptosis through AKT-mTOR pathway in ovarian cancer and renal cancer

Hongrun Chen, Lianfeng Zhang, Meini Zuo, Xiaowen Lou, Bin Liu, Taozhu Fu,

https://doi.org/10.18632/aging.204564 pp 1210—1227

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Correction

Correction for: Bacopaside I ameliorates cognitive impairment in APP/PS1 mice via immune-mediated clearance of β-amyloid

Yuanyuan Li, Xing Yuan, Yunheng Shen, Jing Zhao, Rongcai Yue, Fang Liu, Weiwei He, Rui Wang, Lei Shan, Weidong Zhang,

https://doi.org/10.18632/aging.204531 pp 1228—1229

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