Aging-US: Iron: an underrated factor in aging


Aging-US published "Iron: an underrated factor in aging" which reported that iron is an essential element for virtuall...

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Aging-US: Role of Citicoline in an in vitro AMD model


Aging-US published a Special Collection on Eye Disease which included "Role of Citicoline in an in vitro AMD model" wh...

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Aging’s Latest Impact Factor


BUFFALO, NY-August 20, 2021Aging is indexed by Read More

Three years younger in just eight weeks? A new study suggests yes!


A groundbreaking clinical trial shows we can reduce biological age (as measured by the Horvath 2013 DNAmAge clock) by more than three years in only eight week...

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Aging-US: From causes of aging to death from COVID-19


Aging-US recently published "From Causes of Aging to Death from COVID-19" by Blagosklonny et al. which repor...

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Aging-US: SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2


The cover for issue 12 of Aging-US features "SIRT6 mono-ADP rib...

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Aging-US: COVID-19 and chronological aging: anti-aging drugs for treatment or prevention


Volume 12, Issue 8 of @AgingJrnl reported that similarly, two proposed therapeutics for the treatm...

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Scientist proposes clinical trials w/ low-dose rapamycin to protect elderly from COVID-19


Friday, 3rd of April, 2020, London, UK - The Biogerontology Research Foundation, a registered UK charity supporting and promoting aging and longevity research worldwide since 2008, today announced the publicat...

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Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity


Aging-US Volume 12, Issue 2 reported that Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adip...

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Rapamycin for longevity- opinion article


The scientist discusses several reasons, including fear of the actual and fictional side effects of rapamycin, everolimus and other clinically-approved drugs, arguing that no real side effects preclude their use as an...

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Subunit contribution to NMDA receptor hypofunction and redox sensitivity of hippocampal synaptic transmission during aging


The researchers examined the contribution of N-methyl-D-aspartate receptor subunits in the redox-mediated decline in NMDAR function during aging.

Glu N2A and Glu N2B selective antagonists decreased peak NMDAR c...

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Conclusions from a behavioral aging study on male and female F2 hybrid mice on age-related behavior, buoyancy in water-based tests, and an ethical method to assess lifespan


Due to strain-specific behavioral idiosyncrasies, inbred mouse strains are suboptimal research models for behavioral aging studies.

The researchers found that both males and females demonstrated decreased explo...

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Habitual tea drinking modulates brain efficiency: evidence from brain connectivity evaluation


The researchers recruited healthy older participants to two groups according to their history of tea drinking frequency and investigated both functional and structural networks to reveal the role of tea drinking on br...

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Adipogenic progenitors keep muscle stem cells young


In adult skeletal muscle, loss of myofiber integrity caused by mechanical injuries or diseases are repaired by resident muscle stem cells, called satellite cells, which promptly exit from quiescence after disruption o...

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The effects of dietary fatty acids on bone, hematopoietic marrow and marrow adipose tissue in a murine model of senile osteoporosis


Marrow adipose tissue expansion and associated lipotoxicity are important drivers of age-related bone loss and hematopoietic bone marrow atrophy.

Dr. Gustavo Duque from the Australian Institute for Musculoskele...

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Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging


For Aging’s Volume 11, Issue 18, the Journal devoted the Cover to a research paper by Dr. Alejandro Martin-Montalvo from the Department of Regeneration and Cell Therapy, Andalusian Ce...

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DNA methylation-based estimator of telomere length


Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL.

Leukocyte DNAm TL outperforms LTL in predicting: i)time-to-death, ii)time-to-c...

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Epigenome-wide association study of leukocyte telomere length


In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalus...

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‘Tickle’ therapy could help slow ageing


‘Tickling’ the ear with a small electrical current appears to rebalance the autonomic nervous system for over-55s, potentially slowing down one of the effects of ageing, according to new research.

Scientists fou...

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Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation


Cessation, or even retardation of the ageing process is an appealing notion that has captured the imagination of humans for millennia. Even if it were possible to rejuvenate our bodies or retard the ageing process, ho...

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Sex differences in transcriptomic profiles in aged kidney cells of renin lineage (CoRL)


The researchers found a small core set of genes involved in stemness, proliferation and migration that showed consistent changes with advanced age in cells of renin lineage (CoRL)within the kidney.


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DNA methylation GrimAge strongly predicts lifespan and healthspan


The Grim Reaper arrives for each of us eventually—wouldn’t it be nice to know when? Now UCLA researchers have developed a new tool to help you plan ahead for your date with the Angel of Death.

Named after ...

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Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence-associated secretory phenotype


The specific molecular mechanism of selective release and retention of senescence-associated sEV-mi RNAs and the EV-SASP cross talk between different cell types and its consequences in the context of aging and age-ass...

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Exploiting mitochondrial targeting signal(s), TPP and bis‐TPP, for eradicating cancer stem cells (CSCs)


TPP-related compounds may provide a novel chemical strategy for effectively targeting bulk cancer cells and CSCs, while minimizing off-target side-effects in normal cells.

Several independent lines of eviden...

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