Aging | Probiotics Treatment for Parkinson Disease: A Systematic Review and Meta-analysis of Clinical Trials
09-27-2022“The present study provides evidence for the prescription of probiotics for PwP [people with Parkinson’s disease], especially for their GI symptoms.”
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BUFFALO, NY- September 27, 2022 – A new research paper was published in Aging (listed as “Aging (Albany NY)” by MEDLINE/PubMed and “Aging-US” by Web of Science) Volume 14, Issue 17, entitled, “Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials.”
People with Parkinson’s disease (PwP) exhibit gut dysbiosis and considerable gastrointestinal (GI) symptoms. Probiotics, beneficial strains of microorganisms, and supplements optimize the intestinal environment and alleviate GI symptoms among elderly people.
In a new study, researchers Chien-Tai Hong, Jia-Hung Chen and Tsai-Wei Huang from Taipei Medical University conducted a systematic review and meta-analysis of clinical trials to investigate the effects of probiotics on people with Parkinson’s disease. PubMed, Embase and Cochrane Library databases were used. Six randomized controlled trials (RCTs) and two open-label studies were included. Most of the probiotic regimens were based on Lactobacillus and Bifidobacterium. Six studies investigated the benefit of probiotics for GI symptoms, especially for PwP with functional constipation, and two RCTs assessed probiotics’ effect on systematic metabolism and inflammation. Major outcomes were the effects of probiotics on GI symptoms, including bowel movement and stool characteristics.
“In the meta-analysis, probiotic treatment significantly increased the frequency of bowel movements among PwP (mean difference [MD]: 1.06 /week, 95% confidence interval [CI]: 0.61 to 1.51, p < 0.001, I2 = 40%). Additionally, probiotic treatment significantly normalized stool consistency (standard MD: 0.61, 95% CI = 0.31 to 0.91, p < 0.001, I2 = 0%).”
Although the probiotic compositions varied, the researchers found that probiotic treatment significantly attenuated constipation for people with Parkinson’s disease and exhibited possible systematic effects on inflammation and metabolism. Given the tolerability of probiotics, the present meta-analysis may provide more consolidated evidence of the benefit of probiotics on constipation in people with Parkinson’s disease and a possible new therapeutic approach for disease modification.
“This review and meta-analysis determined that probiotic treatments, mainly Lactobacilli and Bifidobacterium–based regimens, effectively alleviated constipation. Adverse effects are generally tolerable. However, considering the gut microbiota is highly associated with a person’s environment and diet, studies from other continents are required to establish the benefit of probiotics on constipation. Moreover, probiotic treatment is likely to affect the systemic inflammation and metabolism of PwP, but further studies are warranted to investigate the possibility of the disease modification effect on PD.”
DOI: https://doi.org/10.18632/aging.204266
Corresponding Author: Tsai-Wei Huang – Email: tsaiwei@tmu.edu.tw
Keywords: Parkinson disease, probiotics, constipation, meta-analysis
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About Aging-US:
Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.
Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).
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