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Aging-US: Deductive reasoning & principles of particle physics applied to aging research

10-25-2021

Aging-US published "Applying deductive reasoning and the principles of particle physics to aging research" which reported that aging research currently lacks a common conceptual framework, and one challenge in establishing it is the fact that aging is a highly complex process.

To help develop a framework of standard aging rules, the authors suggest the use of deductive reasoning based on particle physics' principles. They discuss how having a common ground may benefit aging research, introduce the logic of new principles and analyze specific examples of how this framework could be used to study aging and design longevity interventions.

Dr. Alibek Moldakozhayev from The McGill University "Aging is a term used to describe a process consisting of myriads of genetic, molecular, environmental, and stochastic deleterious events, leading to a progressive loss of functionality."

Figure 1. Schematic representation of an interaction-transformation principle. Upper case letters represent objects; lower case letters represent interaction/force carriers. Transformation of objects (A to C, B to D) happens following the interaction driven by carriers (a and b). The interaction results in a change of the physical state of the object. Carrier “a” of object “A”, carrying a part of the physical state of object “A” now becomes a part of object “B”, leading to the transformation of object “B” into object “D” and the other way around.

Aging research is a multidimensional and multidisciplinary field; this complexity makes it difficult for those studying this process to have common ground, even when discussing the most fundamental aspects of aging. Despite being a subject of numerous studies over the last two centuries, there is currently no consensus on the nature of aging, e.g., there is a lack of agreement on whether aging is programmed, what its main mechanisms are, how it is related to mortality rate, functional decline and damage accumulation, when it begins, and how it can be managed. In essence, it lacks a foundation on which various researchers can build the knowledge base for the field.

There was an attempt to establish aging axioms that would play a role in the aging paradigm. This could be due to the possible lack of several essential features that would allow us to understand aging better from the perspective of natural science.

There are two ways to consider aging and any other process: deductive and inductive reasoning.

There are two ways to consider aging and any other process: deductive and inductive reasoning

Most theories on aging are based on inductive reasoning, i.e., offer a transition from specific observations to generalized principles of aging.

The Moldakozhayev Research Team concluded in their Aging-US Research Output, "These principles suggest that effective anti-aging interventions would be the tools that postpone or abolish the thresholds for specific transformations at discrete levels, or methodologies, leading to slowing down the rate of transformation of a system from a functional to damaged state or to the transformation of a system from a damaged to a functional state."

Full Text - https://www.aging-us.com/article/203555/text

Correspondence to: Alibek Moldakozhayev email: alibek.moldakozhayev@mail.mcgill.ca

Keywords: aging, damage, framework, particle physics, theory

About Aging-US:

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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