Research Perspective Volume 2, Issue 6 pp 369—374
Sestrins at the crossroad between stress and aging
- 1 Laboratory of Gene Regulation and Signal Transduction, Departments of Pharmacology and Pathology, School of Medicine, University of California San Diego (UCSD), La Jolla, CA 92093-0723, USA
- 2 Development and Aging Program, Neuroscience, Aging and Stem Cell Research Center, Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA
- 3 Section of Cell and Developmental Biology, UCSD, La Jolla, CA 92093-0349, USA
Received: June 9, 2010 Accepted: June 12, 2010 Published: June 13, 2010
https://doi.org/10.18632/aging.100157How to Cite
Abstract
Sestrins are a family of stress-inducible proteins that can function as antioxidants and as inhibitors of target of rapamycin complex 1. In this research perspective, we discuss the possible roles of Sestrins in diverse stress-induced patho-physiological contexts that can result in premature aging and age-related diseases. We suggest that Sestrins provide critical feedback regulation that adjust metabolic and stress responses to different environmental cues and evolutionary constraints.