The implication of Sir2 in replicative aging and senescence in <i>Saccharomyces cerevisiae</i>

Cheol Woong Ha; Won-Ki Huh

doi:10.18632/aging.100299

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Research Perspective Volume 3, Issue 3 pp 319—324

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

Cheol Woong Ha^1, , Won-Ki Huh ,

¹ School of Biological Sciences, Research Center for Functional Cellulomics, and Institute of Microbiology, Seoul National University, Seoul 151-747, Republic of Korea

Received: March 9, 2011 Accepted: March 13, 2011 Published: March 13, 2011

https://doi.org/10.18632/aging.100299
How to Cite

Copyright: © 2011 Ha et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The target of rapamycin (TOR) pathway regulates cell growth and aging in various organisms. In Saccharomyces cerevisiae, silent information regulator 2 (Sir2) modulates cellular senescence. Moreover, Sir2 plays a crucial role in promoting ribosomal DNA (rDNA) stability and longevity under TOR inhibition. Here we review the implication of rDNA stabilizers in longevity, discuss how Sir2 stabilizes rDNA under TOR inhibition and speculate on the link between sumoylation and Sir2-related pro-aging pathways.

Featured Nobel Articles

Research Perspective Volume 3, Issue 3 pp 319—324

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

Cheol Woong Ha^1, , Won-Ki Huh ,

Received: March 9, 2011 Accepted: March 13, 2011 Published: March 13, 2011

Abstract

Corresponding Author

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Featured Nobel Articles

Research Perspective Volume 3, Issue 3 pp 319—324

The implication of Sir2 in replicative aging and senescence in Saccharomyces cerevisiae

Cheol Woong Ha1, , Won-Ki Huh ,

Received: March 9, 2011 Accepted: March 13, 2011 Published: March 13, 2011

Cite this Article

How to cite

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Abstract

Corresponding Author

Special Collection

Keywords

Cheol Woong Ha^1, , Won-Ki Huh ,